Example sentences for: ifng-induced

How can you use “ifng-induced” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • This possibility appears particularly important since the specific lack of CIITA inducibility was cited as the most common basis for lack of IFNg-induced MHCII expression among Rb-positive human tumor lines [ 13 21 ] .

  • In certain types of tissues, ethanol has been shown to induce membrane translocation of PKC isoforms through activation of phospholipase A and release of diacylglycerol [ 40 ] . This mechanism, however, does not appear to be significant in our case as ethanol without PMA failed to potentiate IFNg-induced MHCII expression in LS1034 cells.

  • Taken together, the above results showed a strong potentiating effect of PMA on IFNg-induced HLA-DR expression in LS1034 cell line and no changes in two other poorly inducible cell lines.

  • It remains to be determined whether the restoration of IFNg-induced MHCII expression by PMA is unique to LS1034 cells.

  • However, if clinically tested PKC agonists such as Bryostatin 1 are able to rescue the IFNg-induced MHCII expression within the tumor bed, it might be appropriate to consider them for trials to improve the clinical efficacy of cancer immunotherapy.


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