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Example sentences for: ifngr

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Another reported mechanism of IFNg resistance in tumor cells is associated with down-regulation of IFNg-receptors [ 38 ] . The relevance of this mechanism to MHCII inducibility was recently supported by the evidence that PMA is able to enhance IFNg-dependent MHCII expression in THP-1 human leukemia cells through the up-regulation of IFNg receptors [ 19 ] . In our experiments, however, the incubation of LS1034 cells with PMA and ethanol did not lead to any changes in IFNgR expression as determined by flow cytometry (Figure 4).
Moreover, the level of IFNgR1 in HepG2 cells actually drops after exposure to PMA.
Results, plotted in Figure 4, show that untreated and PMA-treated tumor cells express about the same levels of IFNgR1 and IFNgR2.
interferon-gamma receptor alpha-chain IFNgR1
Therefore, it is unlikely that up-regulated IFNgR contributed to the phenomena reported here.