Words similar to ifng-resistant

Example sentences for: ifng-resistant

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Previously, PMA was shown to augment IFNg-mediated MHCII expression in MHCII-inducible tumor cell lines [ 19 20 ] . Here, we report that the presence of PMA in tissue culture restores IFNg-dependent MHCII expression in the poorly-responding LS1034 colon carcinoma cell line but fails to produce this effect in two other IFNg-resistant cell lines, MSTO-211H mesothelioma and HepG2 hepatocellular carcinoma.
Specifically, the influence of a potent PKC activator, PMA, and clinically tested drug, Bryostatin 1, on the IFNg-induced MHCII expression in several IFNg-resistant tumor cell lines was examined.
Given the role that MHCII may play in tumor immunity, further attempts to restore inducibility in IFNg-resistant tumors appear to be warranted.
Whether or not this phenomenon may be reproduced with other IFNg-resistant colon carcinoma cell lines is of particular interest, since colonic epithelium is physiologically exposed to PKC activators that enhance cytokine signalling in enterocytes during inflammatory responses within the intestinal mucosa [ 42 ] .