Words similar to ifng-dependent

Example sentences for: ifng-dependent

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Bryostatin 1 may be considered for further investigation of IFNg-dependent MHCII induction in resistant tumors in vivo .
We also show that the IFNg-dependent MHCII expression in LS1034 cell line can be rescued by clinically acceptable concentrations of Bryostatin 1.
Another reported mechanism of IFNg resistance in tumor cells is associated with down-regulation of IFNg-receptors [ 38 ] . The relevance of this mechanism to MHCII inducibility was recently supported by the evidence that PMA is able to enhance IFNg-dependent MHCII expression in THP-1 human leukemia cells through the up-regulation of IFNg receptors [ 19 ] . In our experiments, however, the incubation of LS1034 cells with PMA and ethanol did not lead to any changes in IFNgR expression as determined by flow cytometry (Figure 4).
This may suggest that either the two PKC activators act through different isoforms of PKC or PMA also activates enzymes outside the PKC family such as MAPK [ 18 ] . Whatever the mechanism, it appears possible to restore the IFNg-dependent MHCII expression in LS1034 cell line by clinically acceptable concentrations of Bryostatin 1.
It has been previously shown that potentiating effect of phorbol esters on IFNg-dependent MHCII induction in THP-1 monocytic cell line was associated with the increase in synthesis of IFNg receptors [ 19 ] . For that reason, we questioned whether PMA could produce similar changes in LS1034 colon carcinoma cells.