Words similar to ifng-dependent

Example sentences for: ifng-dependent

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We also show that the IFNg-dependent MHCII expression in LS1034 cell line can be rescued by clinically acceptable concentrations of Bryostatin 1.
Another reported mechanism of IFNg resistance in tumor cells is associated with down-regulation of IFNg-receptors [ 38 ] . The relevance of this mechanism to MHCII inducibility was recently supported by the evidence that PMA is able to enhance IFNg-dependent MHCII expression in THP-1 human leukemia cells through the up-regulation of IFNg receptors [ 19 ] . In our experiments, however, the incubation of LS1034 cells with PMA and ethanol did not lead to any changes in IFNgR expression as determined by flow cytometry (Figure 4).
Bryostatin 1 may be considered for further investigation of IFNg-dependent MHCII induction in resistant tumors in vivo .
It has been previously shown that potentiating effect of phorbol esters on IFNg-dependent MHCII induction in THP-1 monocytic cell line was associated with the increase in synthesis of IFNg receptors [ 19 ] . For that reason, we questioned whether PMA could produce similar changes in LS1034 colon carcinoma cells.
To evaluate potential clinical implications of our findings, we asked whether the IFNg-dependent MHCII expression in LS1034 cells could be restored by clinically achievable concentrations of PKC agonists.