Words similar to ifng

Example sentences for: ifng

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Linear regression analysis also revealed that the effect of ethanol was more pronounced at 10 2IU/ml IFNg.
Unfortunately, the induction of MHCII on tumor cells by IFNg in vivo is difficult [ 10 ] . In fact, the reported inducible tumors seem to be limited to freshly transplanted tumor cells [ 9 11 ] or malignant cells present in the ascitic fluid [ 12 ] . Many tumors do not express MHCII after treatment with recombinant IFNg in vitro either [ 13 ] .
A substantial percentage of human tumors lose the expression of the retinoblastoma tumor suppressor protein (Rb), important as a necessary condition for IFNg-mediated induction of MHCII [ 21 ] . Therefore, we wished to determine whether the poor IFNg inducibility of MHCII in LS1034, MSTO-211H and HepG2 cell lines could be explained by the loss of Rb.
Indeed, the CD4+ T cells that directly destroy MHCII-positive tumors were identified [ 5 ] . In the clinic, the expression of MHCII on colorectal carcinomas is correlated with more favourable prognosis [ 6 ] . Adoptive transfer studies show that ex vivo activated CD4+ T cells are able to recognize, and to eliminate, MHCII-positive tumors either by themselves [ 7 ] or in co-operation with CD8+ T cells [ 8 ] . It has been also demonstrated that the increased MHCII expression on tumor cells and macrophages following treatment with IFNg in vivo was associated with enhanced efficacy of adoptive T cell therapy in a mouse model of metastatic sarcoma [ 9 ] .
interferon-gamma IFNg