Words similar to ifng
Example sentences for: ifng
How can you use “ifng” in a sentence? Here are some example sentences to help you improve your vocabulary:
It was reported that some agents, e.g. histone deacetylase inhibitors [ 14 ] or DNA methylation inhibitors [ 15 ] , can rescue the IFNg inducibility of MHCII in cultured tumor cells.
While the manuscript was under review, results of a clinical trial had been published showing that a systemic combination treatment with IFNg and GM-CSF for as long as 9-weeks failed to induce MHCII on tumor cells in 9 out of 15 hepatocellular carcinoma patients.
Monoclonal antibodies used in the study were: 1) mAb against human HLA-DR,DP,DQ, FITC conjugate (anti-MHCII-FITC), clone Tü39, mouse IgG2a; 2) mAb against human IFNg receptor R1 chain, biotin conjugate, clone MMHGR-1, mouse IgG1; 3) mAb against human IFNg receptor R2 chain, biotin conjugate, clone MMHGR-2, mouse IgG1; 4) mouse IgG2a isotype control mAb, FITC conjugate (IgG2a-FITC); 5) mouse IgG1 isotype control mAb, biotin conjugate; 6) mAb against Rb protein, FITC conjugate (Rb-FITC), clone G3-245, mouse IgG1; 7) mouse IgG1 isotype control mAb, FITC conjugate (IgG1-FITC).
Indeed, the CD4+ T cells that directly destroy MHCII-positive tumors were identified [ 5 ] . In the clinic, the expression of MHCII on colorectal carcinomas is correlated with more favourable prognosis [ 6 ] . Adoptive transfer studies show that ex vivo activated CD4+ T cells are able to recognize, and to eliminate, MHCII-positive tumors either by themselves [ 7 ] or in co-operation with CD8+ T cells [ 8 ] . It has been also demonstrated that the increased MHCII expression on tumor cells and macrophages following treatment with IFNg in vivo was associated with enhanced efficacy of adoptive T cell therapy in a mouse model of metastatic sarcoma [ 9 ] .
The results demonstrated a substantial increase in MHCII expression in LS1034 cell line following combined incubation with PMA and IFNg (Figure 2).
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