Words similar to ifng
Example sentences for: ifng
How can you use “ifng” in a sentence? Here are some example sentences to help you improve your vocabulary:
PMA did not improve IFNg inducibility of MHCII in MSTO-211H and HepG2 cell lines (data not shown).
It is well established that, besides the MHCII molecules, IFNg can induce susceptible tumors to upregulate the expression of MHC class I antigens [ 43 ] , tumor associated antigens [ 44 ] , costimulatory molecules [ 45 ] , and heat shock proteins [ 46 ] . In addition, IFNg may have antimetabolic and antiproliferative influence on certain types of tumor cells [ 47 ] . It has also been suggested that IFNg may cause responding tumor cells to secrete angiogenesis inhibitors [ 48 ] . As it is not known which of those IFNg effects are missing or restored by PMA in LS1034 cells, a thorough evaluation of the possible clinical implications of our in vitro findings is quite difficult.
Four dose levels of IFNg combined with 5 dose levels of PMA and 2 dose levels of ethanol generated 40 groups and the design was replicated 4 times.
It should be noted, however, that we observed a small population of LS1034 cells (about 5-10% of all cells) that demonstrated a modest (3- to 4-fold) increase in MHCII-specific fluorescence after incubation with 10 2-10 4IU/ml IFNg (data not shown).
A poor response of tumor cells to IFNg is in agreement with previous observations that many tumors acquire such resistance upon malignant transformation, possibly important as a mechanism of tumor escape from immune surveillance [ 29 ] . The nature of this phenomenon is complex, and multiple defects that can prevent IFNg responses in tumor lines have been described.
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