Example sentences for: gadd

How can you use “gadd” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • C/EBPα binds to and activates transcription of the gene promoter for the p21 inhibitor of cyclin-dependent kinase (CDK) [ 37 ] . This led to speculation that p21 gene activation may contribute to cell cycle arrest by C/EBPα [ 37 ] . Similarly, suppression of mitotic growth during adipocyte differentiation was associated with C/EBPα activation of the promoters of gadd45 (growth arrest and DNA damage-inducible gene 45), gas2 and gas3 (growth arrest-associated genes 2 and 3) [ 5 6 38 39 ] . However, C/EBPα mutants defective in DNA binding still blocked proliferation [ 25 33 ] . This suggested that direct promoter activation was unnecessary, or redundant, for C/EBPα proliferation arrest [ 18 ] .

  • The Rat Genome U34 array was found to contain probe-sets representing the ER chaperones glucose-regulated protein (GRP) 78, protein disulfide isomerase, GRP94, calreticulin and endoplasmic reticulum protein 29 (EPR29), GADD153 and PERK.

  • The Affymetrix website http://www.affymetrix.comwas searched using the terms 'PEK/PERK', 'GADD153' and the gene names for ER chaperones previously identified as being upregulated during an ER stress response [ 12 ] , and where they were represented by probe-sets on the U34 arrays, corresponding accession numbers were identified.

  • 2% of the abstracts indexed for the gene GADD45B contain the word 'proliferation').

  • Mefloquine (80 μM) upregulated the transcription of four of five ER resident chaperones, GRP78, PDI, GRP94 and calreticulin, GADD153 and PERK (one way ANOVA P < 0.05, n = 20, FC > 1.3, Table 2).


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