Words similar to gadd
Example sentences for: gadd
How can you use “gadd” in a sentence? Here are some example sentences to help you improve your vocabulary:
The Affymetrix website http://www.affymetrix.comwas searched using the terms 'PEK/PERK', 'GADD153' and the gene names for ER chaperones previously identified as being upregulated during an ER stress response [ 12 ] , and where they were represented by probe-sets on the U34 arrays, corresponding accession numbers were identified.
Ferret: "There have been attacks reported nationwide, and those attacks have become notorious for their severity and their capriciousness," said hysterical Giuliani appointee John Gadd, not referring to the NYPD.
Mefloquine (80 μM) upregulated the transcription of four of five ER resident chaperones, GRP78, PDI, GRP94 and calreticulin, GADD153 and PERK (one way ANOVA P < 0.05, n = 20, FC > 1.3, Table 2).
Two highly conserved responses are observed under conditions of endoplasmic reticulum (ER) stress; the ER overload and unfolded protein responses [ 24 25 ] . The unfolded protein response is characterized by generalized suppression of protein synthesis and the specific induction of ER-resident proteins and GADD153 [ 24 ] . The transcription factor nuclear factor kB is activated during the ER overload response, leading to the downstream induction of pro-inflammatory proteins [ 25 ] . Therefore, the transcriptional modulation of GADD153 and IkB by mefloquine suggests that the ER might be a target of the drug.
The upregulation of GADD153 by mefloquine suggests that the drug might affect the function of the ER in neurons, perhaps by disruption of calcium homeostasis.
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