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Example sentences for: gadd

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The genes selected for confirmation were those for cyclin D1, GADD45, GPX, HO-1, HSP70, Mdr-1, QR, prostaglandin H synthase (PGHS), p21WAF1/CIP1 and PLA2.
In neurons, GADD153 is selectively upregulated under conditions of endoplasmic reticulum (ER) stress arising from depletion of calcium stores [ 26 ] . Here, the upregulation of GADD153 was observed after mefloquine treatment in NG108 cells (10 μM for 2 h).
In preliminary experiments utilizing primary rat neurons, we have also observed an upregulation of GADD153 after mefloquine treatment (unpublished data).
Secondly, mefloquine has been shown to cause a striking upregulation of GADD153, a transcription factor selectively modulated under conditions of ER stress [ 8 ] . However, the depletion of the ER calcium pool on the one hand, and a consequent induction of an ER stress response have not been shown to occur simultaneously in intact primary neurons.
Relative transcriptional changes at each concentration for GRP78, GADD153 and PERK are shown in Figure 6. Mefloquine induced no significant change in the levels of λ-tubulin mRNA (Table 2, Figure 6).