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Example sentences for: gadd
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The eleven genes with the lowest (array) P -values are presented in Table 2. The upregulation by mefloquine of transcripts encoding the transcription factors cJun and IkappaB (IkB) and the ER stress protein GADD153 were confirmed by RT-PCR (Table 2, Figure 2).
Mefloquine induced changes in the expression of genes encoding cJun, IkB and the ER stress response protein GADD153.
The Affymetrix website http://www.affymetrix.comwas searched using the terms 'PEK/PERK', 'GADD153' and the gene names for ER chaperones previously identified as being upregulated during an ER stress response [ 12 ] , and where they were represented by probe-sets on the U34 arrays, corresponding accession numbers were identified.
C/EBPα binds to and activates transcription of the gene promoter for the p21 inhibitor of cyclin-dependent kinase (CDK) [ 37 ] . This led to speculation that p21 gene activation may contribute to cell cycle arrest by C/EBPα [ 37 ] . Similarly, suppression of mitotic growth during adipocyte differentiation was associated with C/EBPα activation of the promoters of gadd45 (growth arrest and DNA damage-inducible gene 45), gas2 and gas3 (growth arrest-associated genes 2 and 3) [ 5 6 38 39 ] . However, C/EBPα mutants defective in DNA binding still blocked proliferation [ 25 33 ] . This suggested that direct promoter activation was unnecessary, or redundant, for C/EBPα proliferation arrest [ 18 ] .
Indeed, C/EBPα activates transcription of the p21 [ 37 ] , gadd45 [ 5 6 ] , gas2 and gas3 [ 38 39 ] genes.
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