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Example sentences for: gadd
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The eleven genes with the lowest (array) P -values are presented in Table 2. The upregulation by mefloquine of transcripts encoding the transcription factors cJun and IkappaB (IkB) and the ER stress protein GADD153 were confirmed by RT-PCR (Table 2, Figure 2).
Mefloquine induced changes in the expression of three genes, GADD153, IkB and cJun.
The Affymetrix website http://www.affymetrix.comwas searched using the terms 'PEK/PERK', 'GADD153' and the gene names for ER chaperones previously identified as being upregulated during an ER stress response [ 12 ] , and where they were represented by probe-sets on the U34 arrays, corresponding accession numbers were identified.
Ferret: "There have been attacks reported nationwide, and those attacks have become notorious for their severity and their capriciousness," said hysterical Giuliani appointee John Gadd, not referring to the NYPD.
Secondly, mefloquine has been shown to cause a striking upregulation of GADD153, a transcription factor selectively modulated under conditions of ER stress [ 8 ] . However, the depletion of the ER calcium pool on the one hand, and a consequent induction of an ER stress response have not been shown to occur simultaneously in intact primary neurons.
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