Example sentences for: gad

How can you use “gad” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The studies reported here used a probe that will detect the adult Gad1 mRNA that encodes GAD67 as well as the embryonic alternatively spliced mRNA that can encode GAD25 and GAD44.

  • Although the data reported here do not explain the origin of the cleft palate phenotype, they do indicate that Gad1 is expressed in several additional non-CNS tissues in the mouse embryo.

  • For example, administration of GAD65 to young NOD mice has been shown to prevent insulitis and diabetes [ 8 9 ] , apparently via induction of CD4+ regulatory T cells with a T H 2 phenotype [ 10 ] . Similarly, treatment with immunodominant peptides of myelin can prevent or reverse experimental autoimmune encephalomyelitis (EAE), a T H 1-associated inducible "autoimmune" disorder that is widely used as a model for human multiple sclerosis [ 11 12 13 ] .

  • Gad1 mRNA translation or protein stability can be regulated in mature neurons by the level of GABA [ 30, 31].

  • However, both GAD65 and GAD67 mRNA can be detected in the thymic medullary epithelial cells in mice [ 24 ] . Thus, despite thymic expression of GAD65 and GAD67 at the level of mRNA, NOD mice spontaneously develop autoreactivity to these islet (and brain) expressed proteins, and re-challenge of mice that have been immunized with peptides from GAD65 results in severe anaphylactic reactions.


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