Words similar to down-regulated
Example sentences for: down-regulated
How can you use “down-regulated” in a sentence? Here are some example sentences to help you improve your vocabulary:
In prostate cells, however, SKP2 seems to be a major determinant of p27 degradation, as it is down-regulated by androgen and its overexpression is sufficient to mediate p27 ubiquitylation and degradation.
Tat has been shown to down-regulate mannose receptor, EDF-1, CD3-gamma, and TCR/CD3 surface receptor [ 14 ] . Tat reduces mannose receptor levels and promoter activity in mature macrophages and dendritic cells by interfering with the host transcriptional machinery; resulting in decreased levels of surface mannose receptor needed for Ag (mannosylated albumin uptake) or pathogen capture (Pneumocystis carinii phagocytosis), and eventual delivery to MHC class II-containing intracellular compartments [ 15 ] . EDF-1, a gene down-regulated when endothelial cells are induced to differentiate in vitro , was shown to be down-regulated by Tat at the transcriptional level, resulting in the inhibition of endothelial cell growth and in the transition from a nonpolar cobblestone phenotype to a polar fibroblast-like phenotype [ 16 ] .
It may be that the aberrations induced by this mutant protein were sufficient select for down-regulated expression from the pGS58 vector, or the aberrations may be more severe in E. coli . A second mutation of Wang et al.
Of note, the MGMT gene exhibited down-regulated expression in 22 of the 23 (95.
In the light of the present study, it is possible that the BRF, TAF I 48, and TAF I 95 proteins are also post-transcriptionally down-regulated by targeted proteolysis in the same way as TBP and TAF II 135.
Loading...