Words similar to down-regulated

Example sentences for: down-regulated

How can you use “down-regulated” in a sentence? Here are some example sentences to help you improve your vocabulary:

binding of phosphorylated p27 to SKP2 [ 20 21 ] . SKP2 is down-regulated in resting cells with stable p27, but strongly up-regulated in cells, which progress into S phase [ 27 28 ] . In some tissue culture cells, overexpression of SKP2 is sufficient to induce p27 degradation and S phase entry [ 29 30 31 32 ] , and can cooperate with ras in transformation [ 33 34 ] . Significantly, overexpression of SKP2 has been observed in many cancer cell lines [ 28 35 ] as well as in primary cancer specimens and many of these tumors also display down-regulation of p27 [ 33 36 37 38 ] .
In the light of the present study, it is possible that the BRF, TAF I 48, and TAF I 95 proteins are also post-transcriptionally down-regulated by targeted proteolysis in the same way as TBP and TAF II 135.
Of note, the MGMT gene exhibited down-regulated expression in 22 of the 23 (95.
For each pair of experimental conditions, a gene was considered to be "regulated" if it showed at least a two-fold change in expression level (either up- or down-regulated) between conditions, and "unregulated" if the expression ratio was less than two-fold.
Approximately 80 up-regulated genes and 12 down-regulated genes were identified by cDNA microarray analysis in leukemic LGL cells.