Words similar to down-regulated
Example sentences for: down-regulated
How can you use “down-regulated” in a sentence? Here are some example sentences to help you improve your vocabulary:
Mesangial cells, adult skin fibroblasts and smooth muscle cells from SPARC-null mice proliferate faster than their respective wild-type counterparts in media containing fetal bovine serum (FBS) [ 17 ] . Although embryonic fibroblasts from the SPARC-null mice grow at the same rate as the wild-type cells when they are cultured in FBS, the SPARC-null embryonic fibroblasts exhibit down-regulated proliferation as compared to the wild-type cells when the fibroblasts are cultured in serum-free medium containing insulin as the sole mitogenic factor [ 16 ] . Thus, it appears that the role of SPARC in cell proliferation is cell type and environment dependent.
We then purchased seventeen clones from IncyteGenomics containing cDNA fragments that represent fourteen of the up-regulated and three of the down-regulated genes.
Measurements of mRNA and protein made in many laboratories using diverse methodologies have identified approximately 40 genes that are up-regulated and 25 down-regulated after peripheral nerve injury [ 3 5 6 ] . These regulated genes include members of several classes: G protein coupled receptors, ligand- and voltage-gated ion channels, receptor tyrosine kinases, growth factors, cytokines, neuropeptides, cell cytoskeletal genes, cell surface/extracellular matrix genes, and a miscellaneous group of enzymes.
The potential translational inhibitory effects of the TAR RNA region is mediated by the activation of p68 (the interferon-induced 68-kilodalton protein kinase) kinase, which was down-regulated by Tat during productive HIV-1 infection [ 22 ] .
To our surprise, none of the three down-regulated genes studied exhibited differential expression in Northern blots when the cDNA fragments of these genes were used as probes.
Loading...