Example sentences for: down-regulated

How can you use “down-regulated” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Screening indicated a total of 42 templates confirmed to be down-regulated and 18 up-regulated during the spherical to tubular transition.

  • These and other reports suggest the CD34 glycoprotein is either down-regulated or modified in vitro to a form that is not reactive with the usual anti-CD34 antibodies [ 23].

  • Tat has been shown to down-regulate mannose receptor, EDF-1, CD3-gamma, and TCR/CD3 surface receptor [ 14 ] . Tat reduces mannose receptor levels and promoter activity in mature macrophages and dendritic cells by interfering with the host transcriptional machinery; resulting in decreased levels of surface mannose receptor needed for Ag (mannosylated albumin uptake) or pathogen capture (Pneumocystis carinii phagocytosis), and eventual delivery to MHC class II-containing intracellular compartments [ 15 ] . EDF-1, a gene down-regulated when endothelial cells are induced to differentiate in vitro , was shown to be down-regulated by Tat at the transcriptional level, resulting in the inhibition of endothelial cell growth and in the transition from a nonpolar cobblestone phenotype to a polar fibroblast-like phenotype [ 16 ] .

  • For each pair of experimental conditions, a gene was considered to be "regulated" if it showed at least a two-fold change in expression level (either up- or down-regulated) between conditions, and "unregulated" if the expression ratio was less than two-fold.

  • More recent research has begun to focus on the molecular aspects of diapause, with studies of Bombyx morii , Sarcophaga crassipalis , and Lymantria dispar identifying genes up- and down-regulated during diapause [ 1 4 5 6 7 ] . In order to complete this picture, however, detailed descriptions of the morphological aspects of development spanning diapause are also necessary.

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