Words similar to down-regulated
Example sentences for: down-regulated
How can you use “down-regulated” in a sentence? Here are some example sentences to help you improve your vocabulary:
IGFR, [ 29 ] ], and one study used several cell lines and demonstrated distinct effects of the cell genetic background [ 25 ] . Down-regulated genes include bFGF, FGF-2, Topoisomerase II-α, EGFR,, human HDAC1, as well as cell cycle regulatory genes among others [ 30 31 32 33 34 35 36 37 ] . Regions in the bFGF promoter have been identified as associated with density-dependent down-regulation of bFGF [ 31 ] . The IGF-II P3 promoter is down-regulated as a function of cell density, and a 7-base pair sequence has been identified that plays a critical role in this down-regulation [ 32 ] . Neither the MoMuLV LTR or the htk promoters encode this sequence, although both encode a 10-base pair sequence that is identical to the P3 sequence with an insertion of 3 base pairs at position -1081.
After DNA reassociation, the ratio of bb' /aa' increases from 2 to 4. If expression of another gene is down-regulated 3 times in the tester, the formula is (3a + b) (3a' + b') = 9aa' + bb' + 3a'b + 3ab'.
To our surprise many host cellular genes were down-regulated when comparing HIV-1 infected latent cells to uninfected parental cells.
During the spherical to tubular transitions several genes were indicated using SSH to be down-regulated, such as thymosin-beta 4, mitochondrial cytochrome B, and F1Fo-ATP synthase complex mRNA.
Tat has been shown to down-regulate mannose receptor, EDF-1, CD3-gamma, and TCR/CD3 surface receptor [ 14 ] . Tat reduces mannose receptor levels and promoter activity in mature macrophages and dendritic cells by interfering with the host transcriptional machinery; resulting in decreased levels of surface mannose receptor needed for Ag (mannosylated albumin uptake) or pathogen capture (Pneumocystis carinii phagocytosis), and eventual delivery to MHC class II-containing intracellular compartments [ 15 ] . EDF-1, a gene down-regulated when endothelial cells are induced to differentiate in vitro , was shown to be down-regulated by Tat at the transcriptional level, resulting in the inhibition of endothelial cell growth and in the transition from a nonpolar cobblestone phenotype to a polar fibroblast-like phenotype [ 16 ] .
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