Words similar to down-regulate
Example sentences for: down-regulate
How can you use “down-regulate” in a sentence? Here are some example sentences to help you improve your vocabulary:
Interestingly, the promoter activity of the CD87 gene was shown to decline after infection [ 32 ] , implying that post integration of HIV-1 may in fact down-regulate CD87 gene expression.
Indeed, the use of a constitutively active mutant of PP1 has already been shown to result in pRB-dependent G1 arrest in human cancer cells [ 22 ] . Placing this mutant into the inducible expression system described here has the potential to down-regulate expression of wild-type endogenous PP1.
Tat has been shown to down-regulate mannose receptor, EDF-1, CD3-gamma, and TCR/CD3 surface receptor [ 14 ] . Tat reduces mannose receptor levels and promoter activity in mature macrophages and dendritic cells by interfering with the host transcriptional machinery; resulting in decreased levels of surface mannose receptor needed for Ag (mannosylated albumin uptake) or pathogen capture (Pneumocystis carinii phagocytosis), and eventual delivery to MHC class II-containing intracellular compartments [ 15 ] . EDF-1, a gene down-regulated when endothelial cells are induced to differentiate in vitro , was shown to be down-regulated by Tat at the transcriptional level, resulting in the inhibition of endothelial cell growth and in the transition from a nonpolar cobblestone phenotype to a polar fibroblast-like phenotype [ 16 ] .
Consistent with this prediction, treatment with 0.3 μM norepinephrine for 24 h failed to down-regulate the receptor containing the motif mutated to EESSVAE, although the wild-type receptor with the EESSTSE motif was down-regulated by 35%.
IL-4 can down-regulate the production of proinflammatory and Th1-type cytokines by inducing mRNA degradation and upregulating the expression of inhibitors of proinflammatory cytokines such as IL-1Ra [ 3, 4].
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