Words similar to down-regulate

Example sentences for: down-regulate

How can you use “down-regulate” in a sentence? Here are some example sentences to help you improve your vocabulary:

IL-4 can down-regulate the production of proinflammatory and Th1-type cytokines by inducing mRNA degradation and upregulating the expression of inhibitors of proinflammatory cytokines such as IL-1Ra [ 3, 4].
10) have various expression levels of doubly spliced viral mRNAs, including Tat, Rev, Nef, Vpr, and other accessory proteins, we decided to perform the microarray in a system where Tat was constitutively expressed; asking whether Tat by itself, or in the absence of other accessory proteins, could still down-regulate host cellular genes.
Indeed, the use of a constitutively active mutant of PP1 has already been shown to result in pRB-dependent G1 arrest in human cancer cells [ 22 ] . Placing this mutant into the inducible expression system described here has the potential to down-regulate expression of wild-type endogenous PP1.
Interestingly, the promoter activity of the CD87 gene was shown to decline after infection [ 32 ] , implying that post integration of HIV-1 may in fact down-regulate CD87 gene expression.
To test this hypothesis, we mutated the opossum alpha-2C serines and threonine residues to alanines and valine, respectively, and tested whether the expressed receptors would down-regulate.