Example sentences for: down-regulating

How can you use “down-regulating” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • On the other hand, cAMP is known to participate in the growth and differentiation of varied cell types (including thymocytes), through the transcriptional regulation of specific genes [ 32 33 34 ] . The unique cAMP signaling which specifically targets the expression of the CD8 mRNAs (α and β), suggests that PKA activation may result in the transduction of signals that determine the selection of T lymphocytes in favor of the CD4 +CD8 -lineage, by down-regulating and possibly turning off the expression of the CD8 transcripts.

  • P53 suppresses angiogenesis by down-regulating VEGF and iNOS.

  • Thus, role of partial methylation in down-regulating MGMT cannot be ruled out.

  • In contrast, norepinephrine is more potent at down-regulating the alpha-2B and alpha-2C subtypes, with a concentration of only 70 nM required to produce half-maximal down-regulation.


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