Example sentences for: down-regulation

How can you use “down-regulation” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The human alpha-2C receptor, by contrast, has a DESSAAAE sequence in the same region [Figure 2; [ 22 ] ]. Thus, it is possible that the lack of desensitization and perhaps also down-regulation of the human alpha-2C receptor is due to the fact that there are only two hydroxyl residues in the DESSAAAE motif rather than the four hydroxyl residues in the alpha-2A EESSSSD motif.

  • Considering the inverse correlation between p27 and SKP2 protein levels, we asked whether ectopic SKP2 can forge p27 down-regulation in LNCaP cells.

  • Furthermore, inducing down-regulation of either the EGFR or δ-OR by chronic agonist treatment has little effect on ERK activation by the other receptor in HEK-293 cells, suggesting that these pathways are distinct.

  • MTT analysis and viable cell counts showed that ribozyme-mediated down-regulation of M6P/IGF2R also resulted in increased cell proliferation.

  • Although the mechanism of the host cellular down-regulation remains largely unknown, few reports have attempted to decipher the mechanism of the observed inhibition.


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