Example sentences for: down-regulation

How can you use “down-regulation” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • We examined the effects of ribozyme-induced M6P/IGF2R down-regulation on the growth of cultured MCF-7 cells.

  • A cutoff of twofold up- or down-regulation has been chosen to define differential expression in most published studies [ 1, 2].

  • The relatively short kinetics of surface CD4 down-regulation and the delayed CD8 surface disappearance can be interpreted as a PKC-mediated selection signaling in favor of CD8 +CD4 -/α:β-TCR cells that may operate during intrathymic T cell differentiation.

  • The elimination of the terminal two hydroxyl amino acid residues in the EESSTSE motif is sufficient to prevent down-regulation of the opossum alpha-2C adrenergic receptor.

  • For down-regulation experiments the cells were re-homogenized in 5 ml of 25 mM NaPO 4 buffer (pH 7.4).


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