Words similar to down-regulation
Example sentences for: down-regulation
How can you use “down-regulation” in a sentence? Here are some example sentences to help you improve your vocabulary:
The phosphorylated beta-2 receptor enhances the binding of beta-arrestin, which not only uncouples the receptor from the signal transduction process but also serves as an adapter protein that mediates entry into the internalization pathway [ 5 ] , as well as serving as a platform for additional signaling pathways [ 6 ] . The mechanisms of beta-2 adrenergic receptor down-regulation appear to involve both an increase in the rate of degradation of the receptor as well as a decrease in the levels of beta receptor mRNA [ 7 ] . Down-regulation of the beta-2 receptor is, in part, due to trafficking of the beta-2 receptor to lysosomes via the clathrin-coated pit endosomal pathway [ 8 9 ] .
Aberrant promoter methylation changes that occur in cancer are associated with transcriptional repression and loss of function of the methylated gene [ 9 ] . Since we found evidence of down-regulated expression of several methylated genes in CC cell lines, we tested to see if this down-regulation could be reactivated by methylation and HDAC-inhibiting agents.
A cutoff of twofold up- or down-regulation has been chosen to define differential expression in most published studies [ 1, 2].
Functionally, down-regulation of receptors may allow latent HIV-1 infected cells to either hide from the immune system or avoid extracellular differentiation signals normally regulated by receptors.
Hence, macrophage expression of resistin and its induction by LPS is species-specific, but down-regulation of resistin by thiazolidinedione occurs both in rodents and humans.
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