Example sentences for: down-regulation

How can you use “down-regulation” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • We used C6 glioma cells, transfected to stably express the mouse δ-OR, to examine ERK activation by δ-opioids in a line that does not express the EGFR to confirm our results obtained in the receptor down-regulation experiments.

  • Thus, although NGF is an effective anti-apoptotic factor, these actions do not appear to be mediated by down-regulation of potentially death-inducing RPs.

  • Modification of the EESSTSE to EESSVAE was sufficient to prevent down-regulation of the opossum alpha-2C adrenergic receptor.

  • In the presence of the EGFR, ligand activation of LPA and ET-1 receptors did not increase EGFR phosphorylation even though both the LPA and ET-1 receptors stimulated ERK activity by 10-fold over basal [ 27 ] . Specifically, key protein intermediates may be physically associated with endogenous RTKs in HEK-293 cells, and therefore, down-regulation of the EGFR may negatively affect ERK phosphorylation by opioids.

  • We examined the effects of ribozyme-induced M6P/IGF2R down-regulation on the growth of cultured MCF-7 cells.


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