Example sentences for: down-regulation

How can you use “down-regulation” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • To further show the role of hnRNPK in HBV replication, the team tested the effect of over-expression and down-regulation of the cellular protein.

  • In a similar experiment, a 24-hour exposure to DSLET (10 μM) induced significant δ-OR down-regulation and an almost complete loss of DSLET-mediated ERK phosphorylation.

  • The elimination of the terminal two hydroxyl amino acid residues in the EESSTSE motif is sufficient to prevent down-regulation of the opossum alpha-2C adrenergic receptor.

  • Sheridan [ 49 ] and Iaccarino [ 35 ] came to a similar conclusion regarding heart failure and adrenergic down-regulation.

  • Moreover, normal cellular controls on cell-cycle progression appears to be dysregulated by HIV-1 expression because cell-cell contact and differentiation, events that normally lead to the down-regulation of cyclin D 1 expression [ 25 ] , did not significantly alter cyclin D 1 protein levels in HIV-1 infected podocytes.


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