Example sentences for: down-regulation

How can you use “down-regulation” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Current models propose that hormone binding inactivates the receptors, thus resulting in down-regulation of CTR1 activity.

  • Thus, we postulated that the lack of down-regulation in the human alpha-2C subtype is related to having only two rather than four serines in the motif, and that mutating the threonine and serine residues at the end of the opossum EESSTSE motif to valine and alanine residues to give EESSVAE might prevent down-regulation of the opossum alpha-2C receptor.

  • In a similar experiment, a 24-hour exposure to DSLET (10 μM) induced significant δ-OR down-regulation and an almost complete loss of DSLET-mediated ERK phosphorylation.

  • Down-regulation assays

  • The human alpha-2C receptor, which has a DESSAAAE motif with only two hydroxyl residues, does not undergo down-regulation.


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