Example sentences for: dn

How can you use “dn” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Given the internally consistent actions of DN ROCK1 and CA ROCK1, as well as the results employing either FTI-1 or arachidonate, we concluded that the Y-27632 result might be due to inhibition by Y-27632 of protein kinases other than ROCK1 [23].

  • For RT reactions, one microgram of total RNAs was reverse transcribed from random (dN)6 primers in 20 μl of reaction medium containing 1 mM each deoxynucleoside triphosphate, (dN)6 (2 mM), 20 U of RNAsin, 50 mM Tris-HCl, 75 mM KCl, 5 mM MgCl 2 , and 50 U of Moloney murine leukemia virus reverse transcriptase (Applied Biosystem).

  • This result was unexpected in light of the effects of DN ROCK1.

  • CA ROCK1 and DN ROCK1 molecules yielded direct and complementary evidence that ROCK1 was indeed a candidate for modulation of statin-activated α-secretase action.

  • Mutations in TMC1 are responsible for the autosomal dominant human hearing disorder DFNA36 and for the recessive deafness DFNB7/11 [ 5 ] ; the corresponding murine gene Tmc1 also causes deafness in the mutant mouse strains Beethoven ( Bth ) and deafness ( dn ) [ 6 ] . Bth / Bth mice display altered potassium currents in early postnatal cochlear hair cells, in particular Ik,n and Ik,f currents appear to be depressed [ 10 ] . This observation led to the hypothesis that Tmc1 may participate directly or indirectly in regulating the permeability of potassium channels [ 10 ] . Because of the high level of conservation of the amino acid sequences among the eight mammalian TMC proteins (Figure 1, Additional file 1), we speculate that other TMC proteins may as well be modifiers of ion channels or transporters.


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