Example sentences for: dnaa

How can you use “dnaa” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • unknown, but it may have a role in cell division [ 11 ] . RNase P, which consists of the protein subunit RnpA and a catalytic RNA subunit, is essential for generating mature tRNAs by cleaving the 5'-terminal leader sequences of precursor tRNAs [ 16 ] . rpmH encodes ribosomal protein L34, and DnaA is the initiator protein for chromosome replication.

  • The dnaA gene itself is divided into four domains that differ in the extent of sequence homology [ 34 ] . Domain IV is responsible for DnaA box recognition and domain III is a highly conserved region containing the ATP-binding site [ 13 35 ] . Domain I participates in cooperative DnaA protein-DNA interactions [ 36 ] .

  • The relative gene order in this region is also highly conserved in many bacteria, especially the Gram-positives [ 11 ] . Although intergenic sequences in this region are conserved only among closely related organisms, the DnaA box is found in the non-coding regions flanking dnaA in most bacteria studied [ 12 ] . DnaA boxes are conserved nucleotide sequences (TTGTCCACA) where the DnaA protein binds to DNA, triggering events that ultimately lead to replication initiation and DNA synthesis [ 9 ] .

  • The significance of additional dnaA boxes in M. paratuberculosis is likely necessary to open the DNA helix of this GC rich organism (69% GC content).

  • The oriC of Gram-positive bacteria typically contains 10 - 30 of these DnaA boxes, often found in non-coding regions flanking the dnaA gene.


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