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Example sentences for: dnaa

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The non-coding sequences flanking dnaA are slightly AT-rich in general, relative to the rest of the genome sequence, consistent with findings in other gram-positive bacteria (38% - 40% A/T, vs. ~33% in the entire sequence).
The M. smegmatis coding sequence, gnd , has similarity to the 6-phophogluconate dehydrogenase genes in E. coli , but the mycobacterial protein is predicted to be about 200 amino acids shorter than the E. coli homolog . The length of non-coding intergenic regions between rpmH - dnaA and dnaA - dnaN is well conserved among the bacteria shown in figure 2. In many bacteria where a functional oriC has been identified, this gene order is conserved and oriC is adjacent to the dnaA gene [ 9 10 19 ] .
The dnaA gene itself is divided into four domains that differ in the extent of sequence homology [ 34 ] . Domain IV is responsible for DnaA box recognition and domain III is a highly conserved region containing the ATP-binding site [ 13 35 ] . Domain I participates in cooperative DnaA protein-DNA interactions [ 36 ] .
For instance, DnaA monomers bind to specific, non-palindromic 9-nucleotide sequences called DnaA boxes, and this interaction is thought to initiate replication.
In addition, a hexameric sequence thought to be recognized by ATP-DnaA (AGATCT) was found in the 3' non-coding sequence adjacent to dnaA (Fig.