Example sentences for: dnaa

How can you use “dnaa” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Fuzznuc (EMBOSS; http://www.hgmp.mrc.ac.uk/Software/EMBOSS/index.html) was used to identify potential DnaA boxes in the M. paratuberculosis oriC region.

  • The interaction of DnaA with DnaA boxes promotes the local unwinding of a nearby AT-rich region, providing an entry site for the DnaB/DnaC helicase complex.

  • The dnaA gene itself is divided into four domains that differ in the extent of sequence homology [ 34 ] . Domain IV is responsible for DnaA box recognition and domain III is a highly conserved region containing the ATP-binding site [ 13 35 ] . Domain I participates in cooperative DnaA protein-DNA interactions [ 36 ] .

  • The sequence immediately flanking the dnaA gene is considered the origin of chromosomal replication, or oriC region [ 9 10 ] . This region contains several genes that encode proteins required for basic cellular functions, including the protein subunit of RNase P (RnpA), ribosomal protein L34 (RpmH), the replication initiator protein (DnaA), the beta subunit of DNA polymerase III (DnaN), the recombination repair protein RecF, and the DNA gyrase proteins GyrA and GyrB.

  • The dnaA gene is divided into four functional domains based on analysis of several dnaA mutants [ 24 ] . These domains consist of (1) an area near the N-terminus thought be involved in ability of the DnaA protein to aggregate, (2) ATP binding, (3) a domain that maps to a region near the C-terminus and is involved in DNA binding, (4) and a final domain of unknown function, but may bind DnaB.


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