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Example sentences for: dnan
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The B-subunit of DNA polymerase is encoded by dnaN . The recF gene product is involved in recombination, DNA repair, and induction of the SOS response, and may also have a role in replication [ 17 ] . Bacterial DNA gyrase, a tetramer consisting of A and B subunits, catalyzes the ATP-dependent unwinding of covalently closed circular DNA [ 18 ] . The remaining predicted ORFs in this region have high similarity to hypothetical proteins from M. tuberculosis (Table 1).
The sequence immediately flanking the dnaA gene is considered the origin of chromosomal replication, or oriC region [ 9 10 ] . This region contains several genes that encode proteins required for basic cellular functions, including the protein subunit of RNase P (RnpA), ribosomal protein L34 (RpmH), the replication initiator protein (DnaA), the beta subunit of DNA polymerase III (DnaN), the recombination repair protein RecF, and the DNA gyrase proteins GyrA and GyrB.
The M. smegmatis coding sequence, gnd , has similarity to the 6-phophogluconate dehydrogenase genes in E. coli , but the mycobacterial protein is predicted to be about 200 amino acids shorter than the E. coli homolog . The length of non-coding intergenic regions between rpmH - dnaA and dnaA - dnaN is well conserved among the bacteria shown in figure 2. In many bacteria where a functional oriC has been identified, this gene order is conserved and oriC is adjacent to the dnaA gene [ 9 10 19 ] .
The fast growing M. smegmatis species contains a gnd sequence between dnaN and recF , which is absent in the slow-growing mycobacteria (Fig.
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