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Example sentences for: dmsabc
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Furthermore, the spacing between the Fnr and RNA polymerase recognition sequences is critical at dmsA . In vitro interactions of the nitrate-responsive regulatory protein NarL with the promoter region of dmsABC were examined using DNase I and hydroxyl radical footprinting techniques.
This study investigated the effects of sequence changes in the Fnr-recognition site on the anaerobic activation of dmsA-lacZ expression as well as examined the NarL recognition sites within the dmsABC regulatory region.
5 bp from the dmsABC P1 promoter as also established by DNase I footprinting analyses [ 7 8 ] . The presence of nitrate, a preferred alternative electron acceptor, elicits a 10-fold repression of dmsABC expression via the NarXLQP two-component regulatory system [ 4 9 10 ] . Nitrate is detected by either of the two sensor-transmitter proteins, NarX or NarQ, which then activate the DNA binding response-regulatory protein NarL, by phosphorylating an aspartate residue located at position 59.
NarL-phosphate then negatively regulates dmsABC operon expression [ 4 ] . Additional regulators of dmsABC expression have also been described that involve molybdenum dependent gene expression via the ModE transcription factor, and integration host factor (IHF) that interacts with DNA at a downstream site called P2 [ 4 6 11 12 ] . Neither the presence of TMAO nor DMSO, substrates for the DMSO reductase, further modulate dmsABC gene expression [ 4 6 ] .
The location of the NarL-phosphate protected regions within a 97 bp segment of the dmsA promoter is consistent with the model for dmsABC expression whereby multiple molecules of NarL-phosphate recognize and bind to the DNA in a weak and cooperative fashion.
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