Words similar to cdks
Example sentences for: cdks
How can you use “cdks” in a sentence? Here are some example sentences to help you improve your vocabulary:
Under conditions favoring proliferation, the phosphorylation of pRB via cyclin-dependent kinases (CDKs) in mid-to-late G 1 phase results in liberation of E2F and other pRB-bound transcription factors, which then activate the transcription of S-phase genes [ 19 ] . In late M phase, pRB returns to its growth suppressive, hypophosphorylated form due to the action of a pRB-directed protein phosphatase belonging to the type 1 class of serine/threonine protein phosphatases [ 11 20 21 ] .
It is well known that E2F-1 regulates transcription of genes predominantly expressed during the G1 → S transition such as cyclins [ 1, 5], cdks [ 1], E2F-1 gene [ 46], the RB1 tumor suppressor gene [ 8, 47], and genes for DNA replication and repair enzymes and factors [ 4].
Although it is clear that flavopiridol inhibits CDKs, whether flavopiridol inhibits other cellular targets is not known.
p27 specifically inhibits CDKs, which mediate entry into S phase [ 10 11 ] . The level of p27 is higher in quiescent than in proliferating cells, and this increase in p27 abundance is required for an effective cell cycle exit [ 12 ] . The cell cycle-dependent variations in p27 levels are not reflected by similar changes in p27 mRNA [ 13 ] . Many aggressive prostate cancers display decreased p27 protein levels in the presence of high p27 mRNA [ 14 ] , suggesting that p27 depletion may result from ectopic proteolysis.
As most of the CDK inhibitors bind to the ATP-binding pocket of the CDKs [ 17], and all CDKs have similar ATP-binding pockets, it was possible that other CDK inhibitors also inhibit transcription.
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