Words similar to cdks

Example sentences for: cdks

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CKS1, a small protein that associates with CDKs and greatly stimulates p27 ubiquitylation, was recently identified as a forth SCF SKP2component [ 22 23 ] .
It is well known that pRb phosphorylation sites are recognized by specific cdks [ 33], and that most of the 16 pRb-phosphorylation sites are sequentially phosphorylated throughout the cell cycle (reviewed in [ 34, 35]).
As most of the CDK inhibitors bind to the ATP-binding pocket of the CDKs [ 17], and all CDKs have similar ATP-binding pockets, it was possible that other CDK inhibitors also inhibit transcription.
Although it is clear that flavopiridol inhibits CDKs, whether flavopiridol inhibits other cellular targets is not known.
In parallel, the expression of cyclin A, an essential component of certain cyclin-dependent kinases and absolutely required for the progression of cells through the cell cycle [ 38 39 ] , was down-regulated under these conditions (Figure 1), consistent with earlier observations [ 27 28 31 ] . Furthermore, expression of the CDK inhibitor p27 Kip1was strongly increased in suspension cells (Figure 1), similar to what has been observed in other cell types after the disruption of cell-matrix interactions [ 29 31 32 ] . Finally, as we have reported before [ 31 ] , the expression of cdk4, one of the catalytic subunits of CDKs, was not significantly altered in suspension culture cells and therefore could be used as a loading control for the Western blot analysis.