Words similar to cdk-

Example sentences for: cdk-

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Cdk-1 is believed to regulate the G2 checkpoint of the cell cycle and is required to maintain diploidy.
It associates specifically with unduplicated centrosomes, and its phosphorylation by CDK-2/cyclin E, the trigger for centrosome duplication, is required for duplication to occur [ 17 ] . The nucleophosmin gene is also known for its fusion with the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase in cases of this disease with (2;5)(p23;q35) translocations [ 18 ] . The nucleophosmin portion contributes to transformation by providing a dimerization domain, which allows activation of the fused kinase and signal transduction [ 19 ] .
Here, we demonstrate that podocytes expressing HIV-1 genes display the hallmarks of cyclin D 1 -dependent cell-cycle progression, specifically, that cyclin D 1 transcript and protein expression are markedly up-regulated, and that levels of phospho-pRb (Ser780), a target of cyclin D 1 /CDK-4/6 but not cyclin E/CDK-2 complexes [ 24 ] , are induced in vitro and in vivo.
Mutations in Cdk-1 drive cells that would normally remain diploid into endoreplication [ 39].
The expression profile of the cyclin-dependent kinase 1 ( Cdk-1/cdc2 ), is also noteworthy.