Words similar to cdk
Example sentences for: cdk
How can you use “cdk” in a sentence? Here are some example sentences to help you improve your vocabulary:
Rather it corresponds to enhanced binding of p27 Kip1to the cyclin E/CDK2 complex.
Several lines of evidence suggest that the SCF pathway is also conserved in the fission yeast Schizosaccharomyces pombe . Pcu1p, a Cdc53p/CUL1-related protein, was shown to associate with two different F-box/WD repeat proteins, Pop1p and Pop2p, when overexpressed [ 18 ] . In addition, genetic studies demonstrated that both of these F-box proteins are simultaneously required for efficient destruction of Rum1p and the replication initiator Cdc18p [ 18 19 20 ] . Rum1p is a Sic1p-analogous CDK inhibitor, which accumulates in G1, but is degraded as cells enter S phase [ 21 22 ] . Failure to degrade Rum1p is the major phenotypic defect of pop1 and pop2 deletion strains, which leads to disturbance of normal cell cycle progression, resulting in polyploidy [ 18 19 20 23 ] . Based on the genetic data and the biochemical observation that Pop1p and Pop2p interact when overexpressed, a putative SCF Pop1p-Pop2pcomplex was proposed, which would contain the heterooligomerizing F-box proteins Pop1p and Pop2p bound to SCF core components [ 18 20 ] .
9-nitropaullone, the most potent member of a novel class of the paullone CDK inhibitor family, inhibits CDK1/cyclin B at 10-fold lower concentrations than flavopiridol and roscovitine [ 22, 23, 24].
Cyclin E variants in Cdk2 IP were detected by probing with HE12 primary antibody (PharMingen), followed by goat anti-mouse IgG and IgM (Jackson Immunoresearch) secondary antibody conjugated with horse radish peroxidase, and visualized by a chemiluminescent detection system (ECL, Amersham Pharmacia Biotechnology) and autoradiography as indicated above.
Cdc14 subsequently dephosphorylates (and thereby activates) proteins involved in Sic1 expression (Swi5) and C1b degradation (Hct1/Cdh1) [ 19 41 50 ] , thereby eliminating mitotic Cdk activity and promoting exit from mitosis.
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