Example sentences for: cdk

How can you use “cdk” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • When cells harboring conditional-lethal temperature-sensitive (ts) mutations in any of these proteins are shifted to the restrictive temperature, they uniformly arrest in late anaphase as large-budded cells with segregated chromosomes, fully elongated microtubule spindles, and in all tested cases, elevated Cdc28/Clb2 protein kinase activity (Cdc28 is the major cyclin-dependent kinase Cdk1 and Clb2 the major mitosis-specific cyclin of budding yeast) (reviewed in [ 1 ] , [ 2 ] ).

  • In the examples below, a simple model of the cell-cycle kinase Cdk4 begins as a molecule icon to which is appended a 'kinase site' (a square with a K), a 'phosphorylation site' (a circle with a P) and a 'binding site' (a small circle with a dot) (Figure 2a).

  • By counteracting Cdk1-mediated phosphorylations, Cdc14 activates both Hct1/Cdh1, which targets Clb2 for degradation [ 3 4 5 ] , and Swi5, which turns on the transcription of Cdk1 inhibitor Sic1 [ 6 3 ] . Degradation of Clb2 and accumulation of Sic1 act in concert to eliminate mitotic Cdk activity, which is required for exit from mitosis [ 7 ] . Thus, elucidating how Cdc14 is regulated holds the key to understanding how cells exit mitosis.

  • The mechanisms which regulate cyclin H/cdk7 phosphorylation of RARα have not been elucidated.

  • Second, de novo synthesis contributes to the pool of cellular p27 Kip1that is available to bind the cyclin E/CDK2 complex.


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