Example sentences for: cdk

How can you use “cdk” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • p27 is a cyclin-dependent kinase (cdk) inhibitor, and is normally expected to be localized to the cell nucleus.

  • The transient character of these responses may explain the failure to cause efficient S phase entry in the presence of MIB, in particular as co-expression of cyclins was previously shown to synergize with SKP2 in stimulating CDK2 activity and S phase entry [ 30 31 ] . In addition, cyclin A is frequently overexpressed in prostate cancers [ 51 ] . In future experiments, it will be interesting to determine the effect of combined overexpression of SKP2 and cyclin A and cyclin E on cell cycle progression of MIB-arrested cells.

  • In the RARα amino terminus, a consensus mitogen activated protein kinase (MAPK) phosphorylation sequence was found to be a target of cyclin H and cdk7 [ 7 ] . RARα was shown to bind the cyclin H/cdk7 complex in vitro and phosphorylation of serine 77 enhanced the transactivation function of RARα.

  • Loss of this enzymatic activity renders yeast cells temperature-sensitive for growth on galactose medium and hypersensitive to mild mutations in the yeast homolog of mammalian Cdk7, that is, Kin28, the kinase component of general transcription factor TFIIH [ 30].

  • This is not due to a decline in CDK2 or cyclin E protein levels.


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