Words similar to cdk
Example sentences for: cdk
How can you use “cdk” in a sentence? Here are some example sentences to help you improve your vocabulary:
p27 is a cyclin-dependent kinase (cdk) inhibitor, and is normally expected to be localized to the cell nucleus.
The transient character of these responses may explain the failure to cause efficient S phase entry in the presence of MIB, in particular as co-expression of cyclins was previously shown to synergize with SKP2 in stimulating CDK2 activity and S phase entry [ 30 31 ] . In addition, cyclin A is frequently overexpressed in prostate cancers [ 51 ] . In future experiments, it will be interesting to determine the effect of combined overexpression of SKP2 and cyclin A and cyclin E on cell cycle progression of MIB-arrested cells.
In the RARα amino terminus, a consensus mitogen activated protein kinase (MAPK) phosphorylation sequence was found to be a target of cyclin H and cdk7 [ 7 ] . RARα was shown to bind the cyclin H/cdk7 complex in vitro and phosphorylation of serine 77 enhanced the transactivation function of RARα.
Loss of this enzymatic activity renders yeast cells temperature-sensitive for growth on galactose medium and hypersensitive to mild mutations in the yeast homolog of mammalian Cdk7, that is, Kin28, the kinase component of general transcription factor TFIIH [ 30].
This is not due to a decline in CDK2 or cyclin E protein levels.