Words similar to agonist-induced

Example sentences for: agonist-induced

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The human alpha-2C receptor is somewhat unique among the alpha-2 receptors in that it does not appear to undergo agonist-induced down-regulation [ 11 ] . The human alpha-2A adrenergic receptor, which does undergo down-regulation, has an acidic serine motif (EESSSSD) in the third intracellular loop.
Sequentially mutating each of the four serines to alanine decreased the phosphorylation of the receptor by approximately 25% for each serine, and mutating either the first two or the last two serines to alanines prevented agonist-induced desensitization, but not agonist-induced sequestration/internalization [ 12 ] . The influence of mutations in this motif on down-regulation has not been investigated.
In adrenergic receptors, which have been characterized in detail, rapid endocytosis appears to be required for resensitization of receptors following agonist-induced phosphorylation ( 28).
The human alpha-2A adrenergic receptor has an acidic serine-rich motif (EESSSSD) in the third intracellular loop that has been shown to be important in agonist-induced desensitization but not in agonist-induced sequestration/internalization.
Indeed, this motif is not found in the alpha-2B subtype which does undergo agonist-induced down-regulation, although as noted above a highly acidic region appears to be important and could be related to the additional negative charge provided by phosphorylation.