Example sentences for: agonist-induced

How can you use “agonist-induced” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • In vitro studies, carried out on NG108-15 neurohybrid cells which express large numbers of δ-opioid receptors, show that these receptors undergo a rapid agonist-induced desensitization that occurs within minutes and down-regulation that occurs more slowly over several hours ( 4, 7).

  • The human alpha-2A adrenergic receptor has an acidic serine-rich motif (EESSSSD) in the third intracellular loop that has been shown to be important in agonist-induced desensitization but not in agonist-induced sequestration/internalization.

  • The human alpha-2C receptor is somewhat unique among the alpha-2 receptors in that it does not appear to undergo agonist-induced down-regulation [ 11 ] . The human alpha-2A adrenergic receptor, which does undergo down-regulation, has an acidic serine motif (EESSSSD) in the third intracellular loop.

  • All three alpha-2 adrenergic receptor subtypes from nearly all species that have been tested undergo agonist-induced down-regulation [ 24 25 ] . Interestingly, we have shown that the potency of norepinephrine to produce down-regulation differs among alpha-2 receptor subtypes [ 19 24 ] . The concentration of norepinephrine required to produce half-maximal down-regulation is approximately 2 μM for the alpha-2A receptor.

  • Indeed, this motif is not found in the alpha-2B subtype which does undergo agonist-induced down-regulation, although as noted above a highly acidic region appears to be important and could be related to the additional negative charge provided by phosphorylation.


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