Example sentences for: agonist-induced

How can you use “agonist-induced” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • All three alpha-2 adrenergic receptor subtypes from nearly all species that have been tested undergo agonist-induced down-regulation [ 24 25 ] . Interestingly, we have shown that the potency of norepinephrine to produce down-regulation differs among alpha-2 receptor subtypes [ 19 24 ] . The concentration of norepinephrine required to produce half-maximal down-regulation is approximately 2 μM for the alpha-2A receptor.

  • These findings raise two related questions: 1) can δ-opioid receptors be internalized in vivo by the same agonist-induced endocytosis observed in vitro ? and if this is the case, 2) does the internalization process have the same kinetics reported from in vitro studies?

  • Sequentially mutating each of the four serines to alanine decreased the phosphorylation of the receptor by approximately 25% for each serine, and mutating either the first two or the last two serines to alanines prevented agonist-induced desensitization, but not agonist-induced sequestration/internalization [ 12 ] . The influence of mutations in this motif on down-regulation has not been investigated.

  • By contrast, a deletion of twelve residues of the human alpha-2A receptor (293-304) which includes the EESSSSE motif did not appear to prevent agonist-induced down-regulation [ 26 ] . Thus a phosphorylation pathway may not be involved in agonist-induced down-regulation of the alpha-2A adrenergic receptor.

  • The alpha-2 adrenergic receptors also undergo agonist-induced desensitization and down-regulation.


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