Words similar to agonist-induced

Example sentences for: agonist-induced

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By contrast, a deletion of twelve residues of the human alpha-2A receptor (293-304) which includes the EESSSSE motif did not appear to prevent agonist-induced down-regulation [ 26 ] . Thus a phosphorylation pathway may not be involved in agonist-induced down-regulation of the alpha-2A adrenergic receptor.
In vitro studies, carried out on NG108-15 neurohybrid cells which express large numbers of δ-opioid receptors, show that these receptors undergo a rapid agonist-induced desensitization that occurs within minutes and down-regulation that occurs more slowly over several hours ( 4, 7).
The human alpha-2A adrenergic receptor has an acidic serine-rich motif (EESSSSD) in the third intracellular loop that has been shown to be important in agonist-induced desensitization but not in agonist-induced sequestration/internalization.
The human alpha-2C receptor is somewhat unique among the alpha-2 receptors in that it does not appear to undergo agonist-induced down-regulation [ 11 ] . The human alpha-2A adrenergic receptor, which does undergo down-regulation, has an acidic serine motif (EESSSSD) in the third intracellular loop.
Indeed, this motif is not found in the alpha-2B subtype which does undergo agonist-induced down-regulation, although as noted above a highly acidic region appears to be important and could be related to the additional negative charge provided by phosphorylation.