Words similar to agonist
Example sentences for: agonist
How can you use “agonist” in a sentence? Here are some example sentences to help you improve your vocabulary:
These results demonstrate that the binding of the agonist to Smo is reversible and that equilibrium binding will require binding reaction times of approximately 50 hours (five times the t½ of dissociation).
Our data clearly show that nalbuphine is a potent agonist at the μ opioid receptor with an efficacy similar to that of morphine, thus agreeing with in vivo data showing that morphine and nalbuphine are equally potent as analgesics [ 33 ] . However, other reports have described nalbuphine as a "mixed agonist/antagonist" with agonism at κ opioid receptors and antagonism at μ opioid receptors based on in vivo data [ 11 33 ] . This categorization is likely due to the fact that nalbuphine has been shown to reduce the ventilatory depressant effect of other opioids, while adding to their analgesic effect [ 33 ] . Nalbuphine is also used clinically to reduce the opioid-mediated side effects such as itching, without completely reversing the analgesic effects of the full agonists [ 34 35 36 ] . According to our data, although nalbuphine is clearly a potent agonist at μ receptors, its levels of agonism is significantly lower than the very efficacious drug fentanyl and the endogenous ligand β-endorphin.
For EC 50 determinations, responses were normalized to the maximum response obtained from the full agonist 5-HT and fitted to the equation Ψ= 1/1+(EC50/ [C] n), where Ψ is the normalized current at 5-HT concentration [C], EC50 is the concentration of 5-HT needed to obtain half maximal activation and n is the apparent Hill coefficient.
The fully edited rat 5-HT 2C receptor exhibits reduced agonist efficacy or ability to interact with G proteins compared to the unedited receptor (Ile157-Asn159-Ile161) in transfected cells [ 39 ] . Interestingly, 5-HT elicits a larger response (see Fig.
Down-regulation occurs after prolonged agonist treatment (hours to days), resulting in a loss of receptor binding sites [ 2 3 4 ] . The processes involved in homologous desensitization have been extensively investigated for the beta-2 adrenergic receptor, which is the prototypical G protein-coupled receptor.
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