Example sentences for: agonist

How can you use “agonist” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Most of our surrogates have been shown to have either agonist or antagonist activity in the appropriate biochemical and/or biological models ( [ 7 ] manuscripts in preparation).

  • Briefly, if this model is applied to Hh signaling, it proposes that, firstly, agonist and antagonists act at independent sites to select active and inactive conformations of Smo; secondly, that Smo engages an undefined coupler/effector, when it is in its signaling state; and finally, that the gain-of-function mutant form of Smo, Smo act, adopts an abnormal conformation that resembles the coupler/effector-bound signaling state of Smo with low affinity for antagonists but normal affinity for the agonist.

  • These K i values are in general agreement with the agonist EC 50 values in cell culture for these compounds, with the exception that the Hh-Ag 1.1 compound is not as potent in signaling assays (EC 50 2 μM) as its K i (96 nM) might predict.

  • To begin addressing this question, we used the Hh reporter cell line to conduct competition experiments between the Hh agonist and known Hh- signaling antagonists that block the pathway at different levels (Figure 4a).

  • Agonist 1 and 2 both have a carboxylate group which superimposes with the carboxylate of all-trans RA, and makes stabilizing hydrogen bonds with Arg 274 and 278, and the backbone nitrogen of Ser 289 (Fig.

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