Example sentences for: agonist-dependent

How can you use “agonist-dependent” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Our attempts to identify ERβ mutants that differentiate between GRIP1 and N-CoR binding to analyze the role of agonist-dependent corepressor binding have not yet been successful (probably because ERβ utilizes the same surface to bind both cofactors).

  • A peptide overlapping to the N-CoR ID1 motif (amino acids 2265-2291) that competes for N-CoR binding to unliganded TR and RAR [ 16 ] failed to compete for agonist-dependent ERβ interactions with N-CoR.

  • In any case, the fact that ERβ binds weakly or not at all to the three N-CoR ID motifs that mediate interactions with TRs and RARs and, instead, binds in an agonist-dependent fashion to a region in the C-terminus of N-CoR that has not previously been implicated in NR interactions indicates that ERβ recognizes a novel protein sequence motif within N-CoR.

  • Thus, the β-box is sufficient to bind ERβ and is essential for agonist-dependent ERβ interactions with the N-CoR C-terminus.

  • Similar agonist-dependent interactions could be observed between ERβ and the alternate NR corepressor SMRT in vitro (Fig.


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