Words similar to agonists

Example sentences for: agonists

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This report details the rapid discovery of RAR agonists with novel structural features, thanks to a powerful virtual ligand screening approach, and a research strategy where considerations on existing ligands are avoided.
The LBD utilizes a large hydrophobic cleft composed of residues along H3 and H5 to bind IDs [ 17 ] , and a smaller hydrophobic cleft that is composed of residues in the upper part of H3 and H5 and H12 (and corresponds to AF-2) to bind NR boxes [ 18 ] . Thus, agonists promote coregulator exchange by promoting the packing of H12 over the lower part of the ID binding region, an event that simultaneously completes the coactivator binding surface.
This difference in binding site interactions of the antagonist d -tc and the agonists 5-HT and m CPBG could be the result of a slightly different positioning of d -tc in the binding site.
These data demonstrate that the agonists can elicit a biological response in primary cells similar to that produced by Hh protein.
The PGC-1 related protein PERC also binds ERα preferentially, and potentiates ERα activity more strongly than that of ERβ [ 38 ] . We recently observed that ERα binds the C-terminal NR interacting regions of N-CoR and SMRT in the presence of SERMs but not estrogens [ 39 ] . In this study, we report that ERβ interactions with N-CoR and SMRT are promoted by agonists and inhibited by SERMs.