Words similar to agonists
Example sentences for: agonists
How can you use “agonists” in a sentence? Here are some example sentences to help you improve your vocabulary:
Since three out of four PPARγ agonists tested were ineffective, this raises the possibility that the saving effect of 15d-PGJ 2 is not through PPARγ activation.
This difference in binding site interactions of the antagonist d -tc and the agonists 5-HT and m CPBG could be the result of a slightly different positioning of d -tc in the binding site.
The mutagens permit direct selection of clones in which cellular genes have been disrupted and simplify the characterisation of genes associated with recessive mutations [ 1 ] . Mutagenesis of embryo-derived stem (ES) cells, coupled with in vitro genetic screens, has been widely used to analyse gene functions in mice [ 1 ] . These have included screens for mutations in developmentally regulated genes [ 2 3 4 5 ] , in genes regulated by extracellular agonists [ 6 7 ] , and in genes encoding secreted and transmembrane proteins [ 8 9 ] . Characterized mutations include genes involved in intracellular trafficking [ 10 ] , transcriptional regulation [ 11 12 ] , signal transduction [ 7 8 11 13 14 15 ] , neural development [ 16 ] and neural wiring [ 17 ] , and axial patterning [ 18 19 ] . The rapid expansion of the nucleic acid databases has had a tremendous impact on the identification of genes disrupted by gene entrapment.
This is less likely to be the case with agonists since they must produce a conformational change in the protein to exert their effects.
Our finding that the N-terminal peptide is able to stimulate expression of TN much like the whole protein is potentially important because this small peptide may be useful to develop therapeutic agonists or antagonists for wound healing.
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