Words similar to agonists
Example sentences for: agonists
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Initial results showed that CAR is an apparently constitutive transactivator able to activate gene expression in the absence of exogenously added ligands [ 8 9 ] . The first CAR ligands identified, androstanol and androstenol, are inverse agonists that block this constitutive transactivation [ 10 ] . More recently, it has been found that CAR mediates the characteristic response of a subset of drug metabolizing enzymes to a variety of structurally unrelated foreign compounds [ 11 ] . These xenobiotic activators are referred to as "phenobarbital (PB) - like," based on the prototypic effects of the anti-epileptic agent on drug metabolism [ 12 13 14 ] . The most potent activator of murine CAR is the high affinity agonist ligand TCPOBOP (1,4-bis [2-(3,5-dichloropyridyloxy)]benzene) [ 15 16 ] .
Both fentanyl and hydromorphone showed maximal efficacies that were not significantly different compared to that of the endogenous ligand β-endorphin (P > 0.05), thus categorizing them as full agonists compared to β-endorphin.
On the other hand, many synthetic compounds such as the non-steroid anti-inflammatory drugs (NSAIDs) are PPARα and PPARγ agonists [ 27 ] . Since these are agents used clinically for other purposes, it is important to determine whether interaction of these agents with PPARs could modulate atherogenesis in a positive or negative manner.
In other studies, administration of D2 agonists resulted in decreases in hyperinsulinemia associated with obesity [ 36 ] , and it is known that the brain is richly supplied with insulin receptors, including the cortex and striatal areas [ 37 ] , suggesting an intriguing link between insulin resistance, characteristic of obesity, and dopamine-mediated psychiatric symptoms, including ADHD.
In response to physiological agonists that elicit transient [Ca 2+] i changes, only a small fraction of the cPLA 2 translocates.
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