Words similar to agonists
Example sentences for: agonists
How can you use “agonists” in a sentence? Here are some example sentences to help you improve your vocabulary:
These ligands include the antagonists [ 3H]granisetron, d -tc and lerisetron, and the agonists 5-HT and m CPBG.
2shows that the ERβ-LBD bound N-CoR in the presence of agonists and phytoestrogens, but not SERMs.
This finding is significant given prior reports that oxidative stress on RPE is an important contributing factor of age-related macular degeneration [ 5 42 ] . An earlier report also indicated that PPARγ agonists could prevent laser photocoagulation induced choroidal neovascularization in rat eyes and monkey eyes, which suggests the possible application of these agents on the exudative form of age-related macular degeneration [ 43 ] . It is important to note that the other PPARγ agonists tested in this study (ciglitazone, azelaoyl PAF and LY171883) were ineffective in saving cells under the same experimental conditions.
The side-chain of Phe144 contacts the ligands only via its c-alpha an c-beta atoms, and similar interaction can occur with a leucine or glutamine at this position; however, while the conformation presented is projecting away from the ligands, alternative conformers could bring the side-chain closer to the agonists, and represent structural determinants for specificity.
Prostaglandin E 2 is a major cyclooxygenase metabolite of arachidonic acid which exerts diverse effects on vascular smooth muscle tone and epithelial solute transport via G-protein coupled receptors [ 1 2 ] . At least four distinct G-protein coupled PGE 2 receptors have been cloned: the EP 1 , EP 2 , EP 3 , and EP 4 [ 1 ] . Pharmacological studies suggest PGE 2 relaxes vascular smooth muscle through two of these receptors, the EP 2 and EP 4 receptors, which couple to cyclic-AMP generation [ 3 ] . In contrast, PGE 2 constricts other vascular smooth muscle through EP 3 receptors which inhibit cAMP generation via G i or EP 1 receptors which increase Ca 2+mobilization [ 3 ] . Although both EP 2 and EP 4 receptors relax smooth muscle, EP 2 receptors are uniquely sensitive to the agonists butaprost and AH13205 [ 3 4 ] . Previous studies have shown that PGE 2 increases the cAMP concentration in many tissues including kidney, intestine and uterus, but the relative contribution of EP 2 versus EP 4 receptors to these effects is incompletely defined [ 5 6 ] . Recent studies in mice with targeted disruption of these receptors have suggested an important role for EP2 receptor in regulating systemic hemodynamics.
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