Words similar to upregulation
Example sentences for: upregulation
How can you use “upregulation” in a sentence? Here are some example sentences to help you improve your vocabulary:
The microarray data produced by Preuss and other researchers also indicate that many of the gene expression changes that have occurred during brain evolution involve gene upregulation.
The first, the ER overload response, triggers the activation of the transcription factor NFkB and the subsequent upregulation of inflammatory proteins [ 13 ] . The second, the unfolded protein response (UPR) induces three divergent cellular events: (i) the activation of transcription factor ATF6 leading to the upregulation of ER chaperones such as protein disulfide isomerase, (ii) upregulation of the pro-apoptotic transcription factor GADD153 and (iii) suppression of protein synthesis via phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) by pancreatic eIF2α kinase (PEK/PERK, [ 11 12 ] ). Upregulation of the ER chaperones, GADD153 and PERK in response to a toxic insult would constitute direct evidence of an ER stress response.
Interestingly, among them we noted a further upregulation of MHC molecules and other interferon-inducible factors.
Monocytes were not followed beyond 4 hours after stimulation with LPS, because of the low numbers of cells retrieved, probably due to upregulation of adhesion molecules (ICAM-1) [ 41 ] .
As the sense transcript codes for a pro-apoptotic gene, the result immediately suggests the interesting hypothesis that upregulation of the antisense RNA species in cancer tissues has functional relevance with respect to suppression of the potentially tumor-suppressing sense gene.
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