Example sentences for: upregulation

How can you use “upregulation” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The upregulation of human TTP occurs rapidly, within the first hour of stimulation.

  • These findings demonstrate that high ambient glucose causes upregulation of CD36 mRNA and protein specifically in human, but not in mouse, PTECs.

  • We show that androgen-induced p27 upregulation is paralleled by p27 stabilization and SKP2 downregulation.

  • Consistent with our prior results, concomitant treatment of IFN-γ and RANKL showed dominance of the IFN-γ upregulation, while pretreatment with RANKL for 2 days showed impaired upregulation.

  • The first, the ER overload response, triggers the activation of the transcription factor NFkB and the subsequent upregulation of inflammatory proteins [ 13 ] . The second, the unfolded protein response (UPR) induces three divergent cellular events: (i) the activation of transcription factor ATF6 leading to the upregulation of ER chaperones such as protein disulfide isomerase, (ii) upregulation of the pro-apoptotic transcription factor GADD153 and (iii) suppression of protein synthesis via phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) by pancreatic eIF2α kinase (PEK/PERK, [ 11 12 ] ). Upregulation of the ER chaperones, GADD153 and PERK in response to a toxic insult would constitute direct evidence of an ER stress response.


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