Example sentences for: upregulates

How can you use “upregulates” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • For instance, exposure of fibroblast-like marrow MSCs in vitro to optimal concentrations of dexamethasone, ascorbic acid and β-glycerophosphate induces a cuboidal morphology, upregulates AP and osteocalcin expression, and a mineralized (hydroxyapatite) matrix [ 20].

  • TGF-β upregulates α-smooth muscle actin gene transcription [ 38 ] . Since we identified significant α-smooth muscle actin expression in our model and this coincided with the expression of TGF-β, it is possible that TGF-β mediates α-smooth muscle actin expression in our model.

  • We have previously demonstrated that TGFβ upregulates PTHrP and PAI-1 RNA levels in MDA-MB-231 cells [ 19 ] . TGFβ affected PTHrP expression primarily by increasing the level of the promoter P3-specific transcript [ 19 ] . Quantitative PCR analysis using primers allowing the detection of PTHrP P3 and PAI-1 transcripts indicated that incubation of MDA-MB-231 cells with SB-202190 and SB-203580 greatly inhibited TGFβ-induced increase in PTHrP and, to a lesser extent, PAI-1 mRNA levels (Fig.

  • The first of these examples is the OxyR transcription factor, which upregulates peroxide defenses in

  • Our results show that stimulation of primary cultures of human lung fibroblasts with the proximal cytokine IL-1β upregulates COX-2 protein and mRNA expression to a similar degree in normal and IPF fibroblasts.


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