Example sentences for: upregulates

How can you use “upregulates” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • TGF-β upregulates α-smooth muscle actin gene transcription [ 38 ] . Since we identified significant α-smooth muscle actin expression in our model and this coincided with the expression of TGF-β, it is possible that TGF-β mediates α-smooth muscle actin expression in our model.

  • For instance, exposure of fibroblast-like marrow MSCs in vitro to optimal concentrations of dexamethasone, ascorbic acid and β-glycerophosphate induces a cuboidal morphology, upregulates AP and osteocalcin expression, and a mineralized (hydroxyapatite) matrix [ 20].

  • We have previously demonstrated that TGFβ upregulates PTHrP and PAI-1 RNA levels in MDA-MB-231 cells [ 19 ] . TGFβ affected PTHrP expression primarily by increasing the level of the promoter P3-specific transcript [ 19 ] . Quantitative PCR analysis using primers allowing the detection of PTHrP P3 and PAI-1 transcripts indicated that incubation of MDA-MB-231 cells with SB-202190 and SB-203580 greatly inhibited TGFβ-induced increase in PTHrP and, to a lesser extent, PAI-1 mRNA levels (Fig.

  • Additionally, C-reactive protein reduces endothelial nitric oxide synthase, upregulates the proatherosclerotic NF-κB pathway, enhances low-density lipoprotein (LDL) uptake by macrophages, which become foam cells, and facilitates T-cell- and complement-mediated destruction and apoptosis of the endothelium [2,26,29–31].

  • The first of these examples is the OxyR transcription factor, which upregulates peroxide defenses in


How many words do you know? Try our free vocabulary size test!


Search

Search for example sentences

Loading Loading...
Quantcast