Words similar to upregulate
Example sentences for: upregulate
How can you use “upregulate” in a sentence? Here are some example sentences to help you improve your vocabulary:
SERMs such as tamoxifen can upregulate TGF-β production and activation by many cell types, including human breast cancer cell lines [ 12, 13, 14, 15].
In summary, this descriptive study demonstrates modest regional differences in the mean VEGF mRNA signal in rat gastrocnemius muscles that were induced to upregulate VEGF production by 1 hr. of treadmill running or electrical stimulation.
Chess and coworkers have shown that transforming growth factor-α and hepatocyte growth factor increase the phosphorylation of p44/p42 MAPK in H441 cells [ 23 ] . Epidermal growth factor, which binds to the same receptor as transforming growth factor-α, increases SP-A content in human fetal lung [ 24 ] . Hepatocyte growth factor has also been shown to upregulate the synthesis of SP-A in rat type II cells [ 25 ] . Thus, phosphorylation of p44/42 MAPK may be involved in the up-regulation of SP-A gene expression, results consistent with our observation that inhibition of basal levels of p44/42 MAPK phosphorylation may decrease SP-A gene expression.
Upregulation might engage a feedback loop mechanism, in which Notch activation in neighboring cells maintains them in a proliferative, unspecified state whereas those cells that upregulate Delta expression, and have decreased Notch activity, are driven to exit the cell cycle and to differentiate.
Both protocols have previously been demonstrated to upregulate VEGF mRNA levels by 3-4 fold [ 10 13 14 ] . In situ hybridization with a VEGF 165 probe was then applied to muscle samples to detect the fiber specific localization of VEGF mRNA transcripts.
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