Words similar to upregulate
Example sentences for: upregulate
How can you use “upregulate” in a sentence? Here are some example sentences to help you improve your vocabulary:
SERMs such as tamoxifen can upregulate TGF-β production and activation by many cell types, including human breast cancer cell lines [ 12, 13, 14, 15].
The data are consistent with the report that a variant of PC12 cells also express exclusively PLD2 [ 18 ] and this expression is stimulated by nerve growth factor [ 18 ] , a treatment known to upregulate the cholinergic phenotype of PC12 cells [ 21 22 ] . PLD2 mRNA is abundant in many regions of the adult rodent central nervous system [ 6 23 ] , including cerebellum, frontal cortex, hippocampus, hypothalamus, midbrain, brainstem, striatum, and spinal cord [ 24 ] . The latter three regions are enriched with cell bodies of cholinergic neurons.
More specifically, in the present descriptive study, non-radioactive in situ hybridization with a VEGF 165 probe [ 20 ] was used to visualize the fiber specific localization of VEGF mRNA transcripts on muscle tissue cross sections after muscles were stimulated to upregulate VEGF through exercise or electrical stimulation.
We interpret these data to mean that a subset of proliferative neural precursors upregulate delta gene expression.
The ability of cancer cells to proliferate within a tissue depends on their response to adhesive and growth factor cues within the ECM [ 10 ] , and self-sufficiency in growth signals is one of the hallmarks of cancer [ 11 ] . To stimulate their own growth and proliferation in tissue, tumor cells can overproduce and release their own growth factors or obtain them from the matrix as they are released by matrix metalloproteinases [ 12 ] . The endothelial vasculature grows into the tumor and provides nutrients and oxygen [ 13 ] . This model is illustrated by the experimental results presented here, as both A549 (lung) and U118 (brain) cell lines are observed to upregulate one set of genetic programs related to cell growth and proliferation when in culture and another set related to cell adhesion, the extracellular matrix, growth substances, and neovascularization when developing as an in vivo tumor.
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