Example sentences for: upregulate

How can you use “upregulate” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • All antigen-presenting cells upregulate MHC class II transcription in response to immune stimulation.

  • Another potential explanation is tissue hypoxia, which has been suggested to upregulate Fas in the kidney [ 36 37 ] . MDCK cells in culture demonstrated increased expression of Fas, FasL and FADD in response to partial ATP depletion [ 40 ] . Fas and FasL expression in the kidney may serve as indicators of cellular stress.

  • Similarly, retinoids can upregulate TGF-β production and activation, both in cell culture and in rats in vivo [ 16, 17].

  • The data are consistent with the report that a variant of PC12 cells also express exclusively PLD2 [ 18 ] and this expression is stimulated by nerve growth factor [ 18 ] , a treatment known to upregulate the cholinergic phenotype of PC12 cells [ 21 22 ] . PLD2 mRNA is abundant in many regions of the adult rodent central nervous system [ 6 23 ] , including cerebellum, frontal cortex, hippocampus, hypothalamus, midbrain, brainstem, striatum, and spinal cord [ 24 ] . The latter three regions are enriched with cell bodies of cholinergic neurons.

  • More specifically, in the present descriptive study, non-radioactive in situ hybridization with a VEGF 165 probe [ 20 ] was used to visualize the fiber specific localization of VEGF mRNA transcripts on muscle tissue cross sections after muscles were stimulated to upregulate VEGF through exercise or electrical stimulation.


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