Words similar to upregulate
Example sentences for: upregulate
How can you use “upregulate” in a sentence? Here are some example sentences to help you improve your vocabulary:
Furthermore, experimental evidence suggests that when a signaling network is activated, positive feedback mechanisms upregulate the expression of genes that encode pathway proteins [ 26 ] , implying that this rationale is also applicable to "surveillance" pathways, whose protein components may need to be constitutively present in small quantities, but whose concentration increases with activation.
Antiestrogens such as tamoxifen have been shown to upregulate TGF-β production and activation by many cell types, including human breast cancer cell lines [ 12, 13, 14, 15].
Both protocols have previously been demonstrated to upregulate VEGF mRNA levels by 3-4 fold [ 10 13 14 ] . In situ hybridization with a VEGF 165 probe was then applied to muscle samples to detect the fiber specific localization of VEGF mRNA transcripts.
In summary, this descriptive study demonstrates modest regional differences in the mean VEGF mRNA signal in rat gastrocnemius muscles that were induced to upregulate VEGF production by 1 hr. of treadmill running or electrical stimulation.
The data are consistent with the report that a variant of PC12 cells also express exclusively PLD2 [ 18 ] and this expression is stimulated by nerve growth factor [ 18 ] , a treatment known to upregulate the cholinergic phenotype of PC12 cells [ 21 22 ] . PLD2 mRNA is abundant in many regions of the adult rodent central nervous system [ 6 23 ] , including cerebellum, frontal cortex, hippocampus, hypothalamus, midbrain, brainstem, striatum, and spinal cord [ 24 ] . The latter three regions are enriched with cell bodies of cholinergic neurons.
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