Words similar to substrate
Example sentences for: substrate
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Tyrosine phosphorylation of the substrate domain leads to the recruitment of other downstream adaptors such as crk and nck, as well as other downstream effectors possessing SH2 domains, and signaling events attributed to this domain include activation of the JNK MAPK pathway and control of adhesion and migration of cells [ 6 10 16 38 44 ] . We constructed a chimera between a kinase that phosphorylates Cas in vivo and the substrate domain of Cas, in order to determine events regulated by this domain.
Aliquots of the enzyme solutions were removed over time, diluted and assayed for activity using 1 mM suc-AAPF-pNA substrate in 100 mM Tris pH 8.6 containing 0.0005% Tween-80.
Twenty microliters of blinded sample were applied to the tissue substrate slides.
It has been proposed that vitamin E may incorporate into cellular membranes by association of the tocopherol side chain with the polyenoic fatty acid residues in the membrane fatty acids [ 15 19 ] . This interaction may stabilize cell membranes by making highly unsaturated fatty acids less liable to peroxidation as well as by making highly unsaturated fatty acids less available for phospholipid hydrolysis by phospholipase [ 15 16 ] . The latter action may reduce mobilization of arachidonic acid (AA) from the membranes and in this way reduce the amount of AA available as a substrate to cyclooxygenase and/or lipoxygenase to produce eicosanoids with mitogenic and with inflammatory properties [ 17 20 ] . Other possible antitumor actions include: induction of apoptosis, interference with hormone production, modulation of cellular signaling and gene transcription, and induction of differentiation [ 4 21 22 23 24 ] .
The slides were developed using alkaline-phosphatase substrate to produce the red color.
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