Example sentences for: substitution

How can you use “substitution” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The 'generalist' polymerase contains the single Q758C substitution and the shorter cysteine residue may allow (or at the least not interfere with) a larger range of nucleic acid interactions.

  • We next used this PCR-RFLP assay to assess various patient samples for the presence of the specific 2369 C→T mutation corresponding to the T790M amino acid substitution.

  • The company is investigating the substitution of liquid sodium chloride (salt) as a cleaning agent in place of the dibasic esters/polyethylene glycol process to further the company's goals of toxics use reduction and cost savings.

  • This catenation activity observed with topoisomerase I and Top67 was unlikely to be due to contaminating topoisomerase III activity since it was not observed with the ZD domain purified under almost identical procedures and a site-directed mutant with substitution of the active site Tyr319 by phenylalanine also did not exhibit this activity (Figure 6a).

  • For the substitution rate calculations, the data from 26 bacterial genomes, six archaeal genomes and three mammalian genomes were combined into three kingdom-specific datasets; the remaining eukaryotic genomes were analyzed independently.


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