Words similar to substrate-binding
Example sentences for: substrate-binding
How can you use “substrate-binding” in a sentence? Here are some example sentences to help you improve your vocabulary:
The lack of conserved motifs in the substrate-binding region is consistent with the comparison of the E. coli and human GshB structures, which shows remarkably little similarity in this region of the protein.
In L1, the residue at position 224 is a serine [ 35 ] , and the substrate-binding model for L1 predicts that this serine residue interacts with the carboxylate on substrate via a water molecule [ 37 ] . To test the proposed role of Ser224 in L1, serine was changed to an alanine (S224A), aspartic acid (S224D), and lysine (S224K), and these mutants were characterized using metal analyses, CD spectroscopy, steady-state kinetics, and pre-steady state kinetic studies.
The conserved charged and polar residues conceivably might be involved in catalysis and substrate-binding.
From an evolutionary perspective, the function of proteins within a protein family encompasses both variation, for example, substrate specificity reflected in amino acids lining substrate-binding pockets, and conservation, for example, regions responsible for general enzymatic activity or binding of a common molecular scaffold.
Of these, the small residues preceding strands 3 and 6 contribute a positive φ angle, which results in turning of the C-α backbone to stabilize the β-barrel [ 62 ] . These shared features notwithstanding, the ancient DPBBs have no conserved residues in their catalytic or substrate-binding sites.