Words similar to substrate-binding

Example sentences for: substrate-binding

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Of these, the small residues preceding strands 3 and 6 contribute a positive φ angle, which results in turning of the C-α backbone to stabilize the β-barrel [ 62 ] . These shared features notwithstanding, the ancient DPBBs have no conserved residues in their catalytic or substrate-binding sites.
From an evolutionary perspective, the function of proteins within a protein family encompasses both variation, for example, substrate specificity reflected in amino acids lining substrate-binding pockets, and conservation, for example, regions responsible for general enzymatic activity or binding of a common molecular scaffold.
The substrate-binding model showed that Tyr228 in L1 was position-conserved with Asn233 in the other crystallographically characterized metallo-β-lactamases [ 37 42 44 45 46 ] . Spencer and coworkers postulated that Tyr228 is part of an oxyanion hole that interacts with the β-lactam carbonyl on substrate and helps to stabilize the putative tetrahedral intermediate formed during substrate turnover [ 37 ] . To test this hypothesis, Tyr228 was changed to an alanine and to a phenylalanine to afford the Y228A and Y228F mutants, respectively.
The serine substrate-binding region is highly conserved, as is a monovalent cation (MVC) binding region [ 7] coordinating with G232, F/Y306, and G/A/S308.
The conserved charged and polar residues conceivably might be involved in catalysis and substrate-binding.