Words similar to substrate-binding
Example sentences for: substrate-binding
How can you use “substrate-binding” in a sentence? Here are some example sentences to help you improve your vocabulary:
The serine substrate-binding region is highly conserved, as is a monovalent cation (MVC) binding region [ 7] coordinating with G232, F/Y306, and G/A/S308.
Of these, the small residues preceding strands 3 and 6 contribute a positive φ angle, which results in turning of the C-α backbone to stabilize the β-barrel [ 62 ] . These shared features notwithstanding, the ancient DPBBs have no conserved residues in their catalytic or substrate-binding sites.
The conserved charged and polar residues conceivably might be involved in catalysis and substrate-binding.
predicted that Phe158 and Ile 164 form hydrophobic interactions with bulky substituents on the substrate, suggesting that the loss of these residues would only affect binding of substrates with large aromatic substituents [ 37 ] . In the modeling studies on CcrA [ 42 ] , Asn233 was predicted to interact with the β-lactam carbonyl on substrate, and mutagenesis studies have supported this prediction [ 43 ] . Although Asn233 is sequence conserved in L1 [ 35 ] , it is located 14Å away from the modeled position of the β-lactam carbonyl and was predicted not to play a role in substrate binding to L1 [ 37 ] . On the other hand, the substrate-binding model predicted that Tyr228 was in position to offer a hydrogen bond to the β-lactam carbonyl and participate in an oxyanion hole that was proposed to form as the substrate was hydrolyzed [ 37 ] . By using the crystal structure and modeling studies on L1, Ullah et al.
From an evolutionary perspective, the function of proteins within a protein family encompasses both variation, for example, substrate specificity reflected in amino acids lining substrate-binding pockets, and conservation, for example, regions responsible for general enzymatic activity or binding of a common molecular scaffold.
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