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Example sentences for: substrates

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The best-characterized example of ubiquitin-independent degradation is the degradation of ornithine decarboxylase (ODC), which is dependent upon ODC interaction with the targeting protein antizyme (Az) [ 18 ] . How ubiquitinated substrates or Az-bound ODC is recognized by the 26S proteasome is not well understood.
Instead, we predict that the insertion of an aspartic acid into the active site at position 224 results in a change in the hydrogen bonding network in L1; this hydrogen bonding network is extensive in all metallo-β-lactamases that have been characterized crystallographically [ 37 42 44 45 48 49 62 63 ] . The N233D mutant also exhibited greatly reduced k cat values for biapenem and meropenem but not for imipenem or any of the other substrates tested.
Further mapping of the RNA sequence within VLE that binds Prrp, and possibly DAZAP1, may help to identify the natural substrates of DAZAP1.
The Tyr228 mutants exhibited increased K m values for 8 of the 9 substrates tested, with the smallest changes in K m observed when the carbapenems were used as the substrate.
Table 2 [see Additional file 1] lists the 86 carbon substrates (PM1 plate) catabolized by the sequenced strain 2004, and the number of archival strains (out of 21) that also catabolized these substrates.