Example sentences for: substrates

How can you use “substrates” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • 42] can be used to introduce viral vectors carrying genes encoding an activated form of PI3K, AKT, or candidate substrates for AKT into the mammary tissue of Wnt-1 TG mice.

  • The k cat values exhibited by these mutants for all substrates also differed by less than a factor of 4, except when biapenem and meropenem were used as substrates for the N233D mutant.

  • The 20S proteasome then combines with two 19S regulatory complex to form the 26S proteasome, which is the degradation machinery responsible for both ubiquitin-dependent and ubiquitin-independent degradation [ 37 ] . The prosequences of the proteolytic β subunits are important to keep the proteolytic sites inaccessible to the substrates.

  • In contrast, the results on the Ser224 mutants suggest that this residue is not important in substrate binding, since the S224A and S224K mutants did not exhibit any significant increases (by a factor of ≥ 10) in K m for any of the substrates tested.

  • When the carbapenems were used as substrates however, the changes in K m values were relatively smaller than with the other substrates, and 2- to 37-fold changes in k cat were observed (Table 5).


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