Words similar to ribozyme
Example sentences for: ribozyme
How can you use “ribozyme” in a sentence? Here are some example sentences to help you improve your vocabulary:
To evaluate the bioactivity/specificity of the ribozyme and the accessibility of the target site, a cleavage reaction
To verify whether decreased levels of functional M6P/IGF2R can provide a growth advantage for cancer cells, we used viral and ribozyme strategies to reduce the expression of M6P/IGF2R in human breast cancer cells and then examined the effect on growth and apoptosis of these cells.
The fragments were subcloned into pRz951 to produce a plasmid (designated as pRz-IGF2R) containing a ribozyme targeted against the M6P/IGF2R.
For example, the junction between the aptamer and the Group I ribozyme in the aptazyme Th2P6 resembled the deletion variant td ΔP6-6; the aptazyme was activated by theophylline, while the splicing defect of the deletion variant at 3 mM magnesium was suppressed by 8 mM magnesium or by stabilization of a tetraloop sequence that capped the P6 helix [ 15 ] . Defects that poise a ribozyme between active and inactive conformers have previously been used to engineer effector-dependence [ 20 ] .
In order to convert the Group I self-splicing intron to a regulatable aptazyme, it was necessary to first identify sequences or structures in the ribozyme whose conformation might modulate splicing activity.
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