Words similar to proteasomal
Example sentences for: proteasomal
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First, in a separate report, we showed that Smad1 itself is targeted to proteasome and is subsequently degraded by the proteasome, an event that is triggered by the activation of BMP type I receptor and involves the targeting role of Az and HsN3 [ 39 ] . Proteasomal degradation of Smad1 appears to also play a role in regulating the constitutive level of Smad1 in cell as a way to adjust the cellular responsiveness of BMPs [ 47 ] . However, the targeting mechanism and the regulation involved in these two cases of Smad1 degradation by proteasome are likely fundamentally different [ 39 ] . The second functional outcome of the physical link between Smad1, HsN3 and Az is the ability of Smad1 to regulate the proteasomal degradation of SNIP1, which is clearly dependent upon high levels of Smad1, Az and a strong activation signal from the type I receptor, as suggested by the observations that the protein levels of Smad1, Az and ALK3Q233D directly influence the degree of SNIP1 degradation.
This interaction was suggested to play a role in Tax-induced proteasomal processing of the P105 subunit of NF-κB [ 32 ] . Other proteasome integral components, especially those in the 19S regulator of the 26S proteasome, have also been shown to bring proteins to proteasome for degradation [ 21 ] . Here we identified a unique role of HsN3 in the Az-involved targeting pathway that is coupled to BMP type I receptor activation.
Although there are multiple reports on proteasomal degradation of Smads and Smad interacting proteins, primarily in TGF-β signaling pathways [ 47 48 49 50 51 52 53 54 ] , our observations reported here are entirely based upon our own original observations and show a novel connection of Smads with the proteasome system that no other groups have reported.
0 mcg/ml group relative to the controls suggest that proteasomal inhibition retarded the rate of OM.
1D,1E) suggest that the MG-132-induced transient inhibition of proteasomal and calpain activities during meiosis I predisposed oocytes to abnormal chromosome segregation.
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