Words similar to proteasomal
Example sentences for: proteasomal
How can you use “proteasomal” in a sentence? Here are some example sentences to help you improve your vocabulary:
The protein product of the mdm2 oncogene is over-expressed in a considerable number of tumors [ 27 ] . This protein is a pivotal negative regulator of p53 [ 27 ] ; it interacts with the P53 protein masking its transcriptional domain and accelerating its proteasomal degradation [ 21 27 ] . The later process involves the deacetylation and ubiquitylation of the p53 protein by mdm2 [ 28 ] . Inactivation and/or degradation of p53 diminishes the cell ability to undergo apoptosis [ 21 ] . Conversely, p53 may influence mdm2.
Furthermore, the nuclear co-translocation of Az and HsN3 with Smad1 also suggests potential proteasomal targeting role of Az and HsN3 in the nucleus.
The subject of proteasomal degradation of Smads and Smad interacting proteins has now become a major focus of interest in the field due to its broad implication in signaling regulation and execution.
Post-transcriptional controls appear to be the major regulatory mechanisms that determine the levels of p27 Kip1in the cell [ 26 ] . These include ubiquitination and proteasomal degradation [ 27 ] and sequestration and mislocalization [ 28 ] of the p27 Kip1protein.
The 26S proteasome is responsible for the bulk turnover of cytoplasmic and nuclear proteins in eukaryotic cells and also plays a key role in the regulation of cell cycle, signal transduction, transcription as well as antigen presentation [ 17 18 19 20 21 ] . Most of the known proteasomal substrates are marked and targeted to proteasome by ubiquitination [ 17 19 20 ] . Ubiquitination, however, is not an obligatory step for substrate targeting to proteasome [ 17 18 20 ] . The degradation of the ornithine decarboxylase (ODC), the rate-limiting enzyme for polyamine synthesis, involves a protein named antizyme (Az), which binds and targets ODC to 26S proteasome for degradation [ 18 ] . However, ODC has remained an "orphan" in Az-dependent proteasomal degradation.
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