Words similar to proteasomal
Example sentences for: proteasomal
How can you use “proteasomal” in a sentence? Here are some example sentences to help you improve your vocabulary:
1D,1E) suggest that the MG-132-induced transient inhibition of proteasomal and calpain activities during meiosis I predisposed oocytes to abnormal chromosome segregation.
The 26S proteasome is responsible for the bulk turnover of cytoplasmic and nuclear proteins in eukaryotic cells and also plays a key role in the regulation of cell cycle, signal transduction, transcription as well as antigen presentation [ 17 18 19 20 21 ] . Most of the known proteasomal substrates are marked and targeted to proteasome by ubiquitination [ 17 19 20 ] . Ubiquitination, however, is not an obligatory step for substrate targeting to proteasome [ 17 18 20 ] . The degradation of the ornithine decarboxylase (ODC), the rate-limiting enzyme for polyamine synthesis, involves a protein named antizyme (Az), which binds and targets ODC to 26S proteasome for degradation [ 18 ] . However, ODC has remained an "orphan" in Az-dependent proteasomal degradation.
In a separate study, we also demonstrated that proteasomal degradation also plays an essential role in BMP induced dendritic formation of rat sympathetic neurons [ 44 ] .
The work reported here represents our major efforts during the past several years to follow a novel concept of proteasomal degradation in TGF-β/BMP signaling based upon the yeast two-hybrid data obtained in 1996.
To test the hypothesis that transient inhibition of proteasomal activity during mouse meiosis I was associated with chromosome missegregation, mouse oocytes were exposed in vitro to the reversible proteasome inhibitor MG-132 and metaphase II (MII) oocytes were analyzed for structural and numerical chromosome aberrations.
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