Words similar to proteasomes
Example sentences for: proteasomes
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A small protein Ump1 associates with the premature proteasome complexes and is shown to be involved in assisting the maturation of 20S proteasome, possibly by interacting with the β rings of half proteasomes [ 46 ] . Upon the maturation of the 20S proteasome, Ump1 is trapped inside the proteasome and is degraded by proteasome [ 46 ] . The HSP70 like chaperon protein Hsc73 also associates with the 16S proteasome precursor complexes [ 35 36 ] . The exact role of Hsc73 in 16S precursor proteasome complex is not known, but has been suggested to assist proteasome maturation [ 35 36 ] . Our studies add Smad1, Smad1 interacting proteins such as SNIP1, Smad4, and Az as additional proteins that associate with the assembly intermediates.
Second, the final maturation of the 20S proteasome resulted from the assembly of two half proteasomes into the four stacked ring structure could trap the already bound Smad1 inside the proteasome for rapid degradation or lead to the dissociation of Smad1 from mature 20S proteasome due to the inaccessibility of Smad1 binding site on the incorporated HsN3.
Proteasomes translocated to meiotic spindles of rat oocytes and MG-132 induced-inhibition of proteasomal activity resulted in partial segregation of chromosomes during meiosis I [ 42 ] . Moreover, defective proteasomal activity in fission yeast impaired chromosome segregation [ 38 ] .
In a recent large-scale screen with 1739 yeast proteins used as bait [ 3 ] , midasin (YLR106p) was identified in the polypeptide sets that copurified with four bait proteins, ESS1p, RPT1p, YML029p and HRT1p, that function principally in RNA metabolism and in the regulation of proteasomes (which are mostly intranuclear in yeast [ 50 ] ). However, the interpretation of these proteomic data is clouded by the fact that no protein partners were identified in the complementary experiment in which midasin was itself used as bait.
The APC is a large protein complex that ubiquinates mitotic cyclins and other regulatory proteins that are destined for timely proteolysis by proteasomes [ 10 20 ] . Proteasomes are multicatalytic 26S proteases consisting of a 20S central core catalytic subunit bordered by two 19S components [ 32 33 ] which hydrolyze C-terminal peptide bonds to acidic, basic, and hydrophobic amino-acid residues [ 20 34 ] . Proteasomes proteolyze securins which inhibit separase activity.
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