Words similar to proteasomes
Example sentences for: proteasomes
How can you use “proteasomes” in a sentence? Here are some example sentences to help you improve your vocabulary:
The half proteasomes containing one α and one β rings are further assembled into 20S proteasome, a process involving the proteolytic cleavage of the prosequences of five β subunits, including HsN3.
Proteasomes translocated to meiotic spindles of rat oocytes and MG-132 induced-inhibition of proteasomal activity resulted in partial segregation of chromosomes during meiosis I [ 42 ] . Moreover, defective proteasomal activity in fission yeast impaired chromosome segregation [ 38 ] .
The APC is a large protein complex that ubiquinates mitotic cyclins and other regulatory proteins that are destined for timely proteolysis by proteasomes [ 10 20 ] . Proteasomes are multicatalytic 26S proteases consisting of a 20S central core catalytic subunit bordered by two 19S components [ 32 33 ] which hydrolyze C-terminal peptide bonds to acidic, basic, and hydrophobic amino-acid residues [ 20 34 ] . Proteasomes proteolyze securins which inhibit separase activity.
In a recent large-scale screen with 1739 yeast proteins used as bait [ 3 ] , midasin (YLR106p) was identified in the polypeptide sets that copurified with four bait proteins, ESS1p, RPT1p, YML029p and HRT1p, that function principally in RNA metabolism and in the regulation of proteasomes (which are mostly intranuclear in yeast [ 50 ] ). However, the interpretation of these proteomic data is clouded by the fact that no protein partners were identified in the complementary experiment in which midasin was itself used as bait.
Proteasome activity is required for germinal vesicle breakdown (GVBD) in starfish and toad oocytes [ 44 45 ] and for activating Xenopus oocytes [ 45 46 ] . Also, proteasomes are needed for regulating centrosome segregation [ 38 47 ] , kinetochore structure [ 39 ] , and sister chromatid cohesion and separation [ 48 ] . When rat oocytes were exposed to the proteasome inhibitor MG132, proteasomes translocated to the meiotic spindle, MPF activity was sustained, and oocytes were arrested in MI with partially segregated chromosomes [ 42 ] .
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