Words similar to proteasome-mediated

Example sentences for: proteasome-mediated

How can you use “proteasome-mediated” in a sentence? Here are some example sentences to help you improve your vocabulary:

Characterization of these interactors reveals an unexpected physical and functional link between Smad1 and the proteasome-mediated degradation pathways.
Nonetheless, E2F is inactivated and/or downregulated upon progression to S phase, a regulatory feature that appears critical as E2F overexpression or ectopic activation induces apoptosis both in mammalian cells and in flies [ 12 ] [ 13 ] [ 14 ] [ 15 ] . Inactivation of the DNA-binding activity of E2F-1 by the cyclin A/Cdk complex has been shown to be critical for proper S phase progression [ 16 ] . In mammalian cells, E2F-1 is also subject to proteasome-mediated degradation [ 17 ] [ 18 ] [ 19 ] and recent evidence indicates that E2F-1 degradation occurs in S phase [ 20 ] . Control of E2F-1 stability has also been linked to its association with the F-box protein Skp2 [ 20 ] but this has not been tied to a specific phase of the cell cycle.
However, additional data are clearly needed to further investigate the roles of calpain proteolysis and proteasome-mediated proteolysis on chromosome segregation as well as the numerous other potential molecular mechanisms of aneuploidy.
An increasing body of evidence indicates that targeted 26S proteasome-mediated proteolysis of transcription factors is an integral part of the transactivation process.
We were intrigued by the fact that Smad1 binds to Ub, Az and HsN3, all of which are involved in proteasome-mediated degradation pathways, as illustrated in Fig.