Example sentences for: proteasome-mediated

How can you use “proteasome-mediated” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • However, additional data are clearly needed to further investigate the roles of calpain proteolysis and proteasome-mediated proteolysis on chromosome segregation as well as the numerous other potential molecular mechanisms of aneuploidy.

  • Functional characterization of the interaction between Smad1, Az and HsN3 in the signaling pathways of BMPs led us to find a novel functional link between Smad1 and proteasome-mediated degradation events, through which a novel CBP/p300 repressor, SNIP1 [ 25 ] , is removed to allow the transcriptional activation of BMP-responsive genes.

  • Characterization of these interactors reveals an unexpected physical and functional link between Smad1 and the proteasome-mediated degradation pathways.

  • During this transition, tightly-regulated post-translational phosphorylation-dephosphorylation events and proteasome-mediated proteolytic reactions regulate the activation and inactivation of signal transduction pathways that control chromatin condensation, nuclear membrane dissolution, microtubule nucleation, and formation of a haploid oocyte [ 8 9 10 ] . Several kinases that exert major roles during OM include maturation promoting factor (MPF) [ 9 11 ] , mitogen-activated protein kinases (MAPKs) [ 12 13 ] , and the product of the c-mos protooncogene Mos kinase [ 14 15 ] . Also, during OM oocytes undergo two highly-regulated metaphase-anaphase transitions (MAT) in which homologous chromosomes are equally and randomly segregated to an oocyte and first polar body and a subsequent division in which equational division of sister chromatids results in a haploid oocyte and a second polar body.

  • An increasing body of evidence indicates that targeted 26S proteasome-mediated proteolysis of transcription factors is an integral part of the transactivation process.


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