Words similar to proteasome
Example sentences for: proteasome
How can you use “proteasome” in a sentence? Here are some example sentences to help you improve your vocabulary:
However, the addition of proteasome inhibitor LLnL stabilizes the interaction (Fig.
II 135 in extracts where ubiquitination of RARγ2 can be detected (our unpublished data), at early times we do observe a significant shift in the electrophoretic mobility of TAF II 135 which may correspond to a polyubiquitinated intermediate While the molecular events involved in degradation of transcription factors are in general poorly understood, it is noteworthy that both NRs and TBP have been reported to interact with the proteasome component SUG1 [ [ 60 61 ] ] which may act to target these proteins for degradation.
The proteasome is thus responsible for an important aspect of cellular regulation because the timely and controlled proteolysis of key cellular factors regulates numerous biological processes such as cell cycle, differentiation, stress response, neuronal morphogenesis, cell surface receptor modulation, secretion, DNA repair, transcriptional regulation, long-term memory, circadian rhythms, immune response, and biogenesis of organelles (Glickman and Ciechanover 2002).
Although the overexpressed HsN3 is associated with many other endogenous proteasome components from the COS cells (Fig.
Indeed, a similar explanation has been invoked to explain the presence of Hsp70 and ubiquitin in nuclear aggregates observed in cells expressing abnormal gene products with poly-Gln tracts, such as huntingtin [ 54 ] and ataxin-1 [ 59 ] . Based on reports that overexpression of chaperones [ 59 62 ] or a dominant-negative form of the ubiquitin-conjugating enzyme [ 63 ] can suppress the formation of poly-Gln protein aggregates, Kaytor and Warren [ 58 ] proposed a three-stage model wherein (i) molecular chaperones initially associate with the misfolded protein, (ii) failure to diminish the pool of misfolded protein leads to aggregation and ubiquitination and (iii) inefficient degradation of the aggregate by the proteasome is manifested by the accumulation of inclusion bodies.
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