Words similar to prb
Example sentences for: prb
How can you use “prb” in a sentence? Here are some example sentences to help you improve your vocabulary:
Indeed, if cells depend on cyclin D-mediated G1 → S transition, passage from G 0 through the restriction point in G 1 is dependent on the de novo expression of cyclin D transcript, accumulation of nuclear cyclin D protein, and cyclin D/CDK-4/6 phosphorylation of pRb [ 20 ] . Then, although nuclear-localized cyclin D decreases in S phase in individual cells [ 21 ] , total cyclin D in asynchronously proliferating cell populations remain elevated compared to quiescent cells [ 20 ] . In renal epithelial and mesenchymal cells, cyclin D 1 is the dominant D-type cyclin activated during cell-cycle progression, both during nephrogenesis [ 22 ] and in non-viral-mediated kidney cell proliferation [ 23 ] .
Of critical importance is the question of the in vivo effect of PP1 activity on pRB and growth regulation.
Binding of free E2F/DP heterodimers to E2F sites generally activates transcription of proteins required for G1 → S transition and DNA synthesis [ 1, 2, 3, 4, 5], whereas complex formation with pRb or other pocket proteins including p107 and pRb-2/p130 silences transcriptional activities of downstream target genes [ 6, 7, 8, 9, 10].
[ 20 ] ]. High-risk HPV E6 and E7 gene expression can independently immortalize various human cell types in vitro . The E6 gene interacts with p53 and an apoptotic protein BAK , followed by its degradation, which results in chromosomal instability and resistance to apoptosis [ 21 22 ] . The E7 protein interacts with pRB followed by its degradation [ 23 ] . The p53 and pRB proteins have been shown to play multiple roles in cell growth and in genomic integrity.
Expression of p21 (panel E) is similar to that of cyclin E. The pRb (panel F) shows nuclear expression similar to that of p27, including stromal cells, but no cytoplasmic staining of luteal cells.
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