Words similar to prb

Example sentences for: prb

How can you use “prb” in a sentence? Here are some example sentences to help you improve your vocabulary:

Using this technique, they showed a G1 block by PP1 that was dependent upon the presence of pRB.
The difference in the level of hypophosphorylated pRb pocket protein isoforms between the two cell lines treated with SAHA may be attributed to differences in G1 and S phase cdk activity (examined in the following section).
Binding of free E2F/DP heterodimers to E2F sites generally activates transcription of proteins required for G1 → S transition and DNA synthesis [ 1, 2, 3, 4, 5], whereas complex formation with pRb or other pocket proteins including p107 and pRb-2/p130 silences transcriptional activities of downstream target genes [ 6, 7, 8, 9, 10].
Furthermore, SAHA significantly enhanced the interaction of pRb2/p130 to E2F-4 and the nuclear localization of the pRb2/p130-E2F-4 complex.
These intriguing results indicate that the interaction of hypophosphorylated pRb2/p130 with E2F-4 followed by enhancement in nuclear location after SAHA treatment is a novel mechanism in SAHA-mediating cell growth arrest.