Words similar to prb

Example sentences for: prb

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In order to determine if cyclin D 1 plays a role in this hyperplasia, kidneys from three proteinuric 40-day old transgenic siblings and three non-transgenic littermates were stained by immunohistochemistry with antibody to phospho-pRb (Ser780), a site of cyclin D 1 /CDK-4/6 phosphorylation not targeted by cyclin E/CDK-2 complexes that disrupts pRb/E2F binding for G 1 → S progression [ 24 ] . Figure 1depicts the intense, heterogeneous nuclear staining of glomerular podocytes and tubular epithelium from hyperplastic nephrons in the diseased transgenics versus the absent staining of nephrons in the non-transgenics consistent with the very low mitotic index in normal kidneys of adult animals [ 26 ] . This suggests that cyclin D 1 is promoting cell-cycle progression during the proliferation of epithelium in diseased kidneys.
Our results support the notion that induced PP1α protein functions identically to endogenous PP1α with respect to non-catalytic subunit binding and activity towards phosphorylase a and the tumor suppressor pRB.
Our second approach involved testing immunopurified 6His-HA-PP1α for its ability to dephosphorylate the growth suppressor protein pRB.
Preparation of [ 32P]pRB substrate and pRB-directed phosphatase activity assays
The phosphorylated H1 and pRb bands were scanned and quantitated densitometrically using a Phosphoimager (Molecular Dynamics, Sunnyvle, CA, USA).