Words similar to prb

Example sentences for: prb

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It is well known that pRb phosphorylation sites are recognized by specific cdks [ 33], and that most of the 16 pRb-phosphorylation sites are sequentially phosphorylated throughout the cell cycle (reviewed in [ 34, 35]).
[ 20 ] ]. High-risk HPV E6 and E7 gene expression can independently immortalize various human cell types in vitro . The E6 gene interacts with p53 and an apoptotic protein BAK , followed by its degradation, which results in chromosomal instability and resistance to apoptosis [ 21 22 ] . The E7 protein interacts with pRB followed by its degradation [ 23 ] . The p53 and pRB proteins have been shown to play multiple roles in cell growth and in genomic integrity.
5) and its nuclear localization after SAHA treatment was associated with interaction to E2F-4, equal amounts of nuclear protein extracts were immunoprecipitated with antibodies against E2F-4 followed by western blot analysis against pRb2/p130 antibodies.
SAHA also resulted in the inhibition of G1/S kinase activities and, consequently, hypophosphorylation of the three pRb pocket proteins, which led to G1 cell growth arrest and dramatic decreases in DNA synthesis in both cell lines.
Expression of p21 (panel E) is similar to that of cyclin E. The pRb (panel F) shows nuclear expression similar to that of p27, including stromal cells, but no cytoplasmic staining of luteal cells.