Words similar to prb
Example sentences for: prb
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Preparation of [ 32P]pRB substrate and pRB-directed phosphatase activity assays
Inhibition of cell cycle by p27 and p21 is complemented by retinoblastoma protein pRb, and other cell cycle inhibitors (tumor suppressor proteins) [ 30 31 32 ] . In reality, besides their role in the regulation of the cell cycle, the cdk inhibitors, in association with D-type cyclins, cyclin E, and cdk2, play a direct role in the stimulation of epithelial cell differentiation [ 33 ] . p27 is also transiently expressed in developing myotomes and enhances myogenesis [ 34 ] .
Our results support the notion that induced PP1α protein functions identically to endogenous PP1α with respect to non-catalytic subunit binding and activity towards phosphorylase a and the tumor suppressor pRB.
Our second approach involved testing immunopurified 6His-HA-PP1α for its ability to dephosphorylate the growth suppressor protein pRB.
To examine whether the increase in hypophosphorylation of pRb2/p130 (Fig.
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