Words similar to prb-

Example sentences for: prb-

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Binding of free E2F/DP heterodimers to E2F sites generally activates transcription of proteins required for G1 → S transition and DNA synthesis [ 1, 2, 3, 4, 5], whereas complex formation with pRb or other pocket proteins including p107 and pRb-2/p130 silences transcriptional activities of downstream target genes [ 6, 7, 8, 9, 10].
We identified a novel mechanism for SAHA in cell growth arrest through inhibition in DNA synthesis, concomitant with significant increases in the nuclear localization of pRb-2/p130 associated with E2F-4, decreases in key molecules in DNA synthesis (E2F-1, PCNA and p21), and increases in histone H3 and H4 protein and acetylation levels.
After 30 min, cells were incubated in 2N HCl for 5 min at room temperature prior to incubation with the primary antibody (this step was omitted for pRb-2/p130 immunostaining).
The same sequential steps were followed for pRb-2/p130 immunostaining using anti-pRb-2/p130 monoclonal antibodies (Santa Cruz Biotechnology).