Example sentences for: polyubiquitylation

How can you use “polyubiquitylation” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • SCF Pop1p-Pop2pmediates polyubiquitylation of Rum1p in vitro

  • Thus, CSN deficiency appears to stimulate Pcu3p-associated ubiquitin ligase activity in vitro . A similar stimulation was obtained for substrate-specific polyubiquitylation of phosphorylated Rum1p by SCF Poppurified from csn5 mutants (unpublished observation).

  • A heterooligomeric SCF Pop1p-Pop2pcomplex mediates polyubiquitylation of phosphorylated Rum1p.

  • Genetic experiments suggested that degradation of Rum1p depends on the Pop1p and Pop2p F-box proteins [ 18 20 ] , but also requires phosphorylation of Rum1p on serine 58 and threonine 62 by cyclin-dependent kinase (CDK) [ 21 ] . Thus, phosphorylated Rum1p may be a substrate for SCF Pop1p-Pop2p-mediated polyubiquitylation.

  • Taken together these results strongly suggest that SCF Pop1p-Pop2pmediates the polyubiquitylation of CDK phosphorylated Rum1p in vitro .


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