Words similar to polyunsaturated
Example sentences for: polyunsaturated
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The presence and abundance of long chain polyunsaturated fatty acids (LC-PUFA) in humans diets have been the basis of scientific investigations for decades.
Protein phosphatase 5 has been implicated in the control of cell proliferation, in hormonal signal transduction, and in hsp90 chaperone function [ 3 11 12 13 14 15 16 17 ] . However little is known about the regulation of PP5 or its specific role in these pathways, and only one physiological substrate for PP5 has been identified to date, the apoptosis signaling kinase ASK 1 [ 13 ] . PP5 can be activated by lipid in vitro , and removal of the TPR domain or the C terminus generates an active, lipid insensitive form of the enzyme [ 18 19 20 21 ] . PP5 phosphatase activity is also altered by hCRY2 and a fragment of hsp90 in vitro [ 21 22 ] . These findings suggest that PP5 may be autoinhibited and that the binding of protein partners or lipids to the TPR domain could potentially control PP5 activity in cells, however no reports have yet documented how PP5 is regulated in vivo . The activity of PP5 homologs from cauliflower, T. brucei and P. falciparum is stimulated by polyunsaturated fatty acids in vitro [ 7 8 9 10 ] and removal of the TPR domain from P. falciparum PP5 increases activity to the same extent as lipid treatment [ 8 9 ] . This suggests that the TPR domain plays a similar inhibitory role for all PP5 homologs.
Overall, the SCD subjects had increased proportions of saturated fatty acids in their red cell phospholipids and significantly decreased proportions of polyunsaturated fatty acids (Table 2).
The health benefits or hazards associated with fish consumption will require added attention to origin of fish - marine or fresh water - given the reported differences in stores of polyunsaturated fatty acids and N-3 fatty acid between the two types of fish [ 44 45 46 47 ] . Levels of N-3 fatty acids vary by fish species, oil content of fish, sex and age of fish, and factors exogenous to fish such as water temperature [ 47 48 ] . Oily fish from cold waters (whether marine or fresh bodies of water) are reported to have higher levels of N-3 fatty acids in comparison to fish from warmer bodies [ 45 47 ] . The ratio of N-3 to N-6 fatty acids has recently been suggested as being associated with gestation and birth weight [ 49 ] and this ratio is approximately four-times greater in marine fish in comparison to fresh water fish [ 45 ] . Type and species-specific fish consumption will remain important considerations in assessing exposure scenarios based on fish consumption.
First of all, members of the PP5 class are distinguished by their profound stimulation by polyunsaturated fatty acids [ 19 20 21 30 ] . As shown in Fig.
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