Example sentences for: polyubiquitin

How can you use “polyubiquitin” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The well-known ubiquitin-dependent pathway involves the covalent attachment of ubiquitin to substrate proteins to form polyubiquitin chain, which then targets the marked substrates to proteasome for degradation [ 17 19 20 ] . The ubiquitin-independent pathway is not well defined, but involves targeting proteins other than ubiquitin.

  • As an outcome of this requirement, longer polyubiquitin tags would be preferential substrates for degradation by the proteasome.

  • Extended polyubiquitin chains could slow down chain disassembly, thereby allowing ample time for unfolding and proteolysis of the substrate (Figure 2).

  • Proteins are targeted for proteasome-mediated degradation by attachment of a polyubiquitin chain.

  • A base subcomplex of the RP is pivotal in anchoring polyubiquitin chains during this process, either directly or via auxiliary ubiquitin-binding proteins (Lam et al.


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