Words similar to polyubiquitin

Example sentences for: polyubiquitin

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The well-known ubiquitin-dependent pathway involves the covalent attachment of ubiquitin to substrate proteins to form polyubiquitin chain, which then targets the marked substrates to proteasome for degradation [ 17 19 20 ] . The ubiquitin-independent pathway is not well defined, but involves targeting proteins other than ubiquitin.
As an outcome of this requirement, longer polyubiquitin tags would be preferential substrates for degradation by the proteasome.
While Csn5 is thought to impede the action of ubiquitin ligases through shaving cullins from their Rub1/Nedd8 modification (and possibly also by deubiquitinating substrates bound to the cullins), the outcome of Rpn11 inhibition will depend largely on whether Rpn11 participates primarily in shaving substrates from their chains, promoting release and rescue, or in trimming the polyubiquitin tag, allowing for proteolysis quality control (Figure 2).
Proteins are targeted for proteasome-mediated degradation by attachment of a polyubiquitin chain.
The addition of a polyubiquitin chain to a protein requires the sequential action of a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2) and a ubiquitin-protein ligase (E3) [ 1 ] . E3 activities are thought to be essential because they are involved in substrate recognition.