Words similar to pgi

Example sentences for: pgi

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On the other hand, PGI 2 decreases vascular smooth muscle cell proliferation and collagen and glycosaminoglycane synthesis, via activation of adenylyl cyclase and subsequent production of cAMP [ 17 ] . Betaprost, an analog of PGI 2 , decreases procollagen I and III mRNA expression in cardiac fibroblasts [ 18 ] . These effects may counteract the profibrotic effects seen with TXA 2 and it is possible that an alteration of a "normal" physiologic balance between PGI 2 and TXA 2 could increase tendency towards fibrogenesis.
The ratio of PGI 2 to TXA 2 metabolites was lower in IPF fibroblasts at baseline and with IL-1β stimulation.
Because PGI 2 and TXA 2 have opposing effects in vivo , we calculated the ratio of their metabolites (6-keto-PGF 1α :TXB 2 ) and found a significantly lower ratio in HF-IPF at baseline (0.
COX = cyclooxygenase; HF = human fibroblasts; NL = normal lungs; IPF = idiopathic pulmonary fibrosis; IFN = interferon; IL = interleukin; PG = prostaglandin; TX = thromboxane; PGI 2 = prostacyclin.
2 ), PGF 2α , and 6-keto-PGF 1α (stable metabolite of PGI 2 ) increased modestly in every case, except TXB 2 production by HF-NL, which decreased (0.