Example sentences for: pgia

How can you use “pgia” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • In induced models of autoimmunity, the CD28-B7 interaction has been shown to regulate disease susceptibility by rendering autoreactive T cells anergic, or alternatively by upregulating the threshold for autoreactive T-cell activation [ 30 ] . Furthermore, we previously showed that impaired Fas-mediated activation-induced cell death (AICD) of autoreactive T-helper-1 cells may be responsible for the development of PGIA [ 20 ] . Therefore, AICD and/or T-cell anergy, but not the CD4 +CD25 +regulatory T cells, may be responsible for deletion or inactivation of autoreactive T cells in autoimmune arthritis.

  • To further investigate whether the CD4 +CD25 +T cells play a role in PGIA, we performed adoptive transfer experiments using SCID mice as recipients.

  • No suppression of development of PGIA in SCID mice was observed.

  • To further evaluate the role of the CD4 +CD25 +cells in PGIA, an adoptive transfer system was employed.

  • This observation suggests that the CD4 +CD25 +regulatory T cells might not be involved in the development of PGIA.


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