Words similar to pgia

Example sentences for: pgia

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Our data suggest that the CD4 +CD25 +regulatory T cells might not be essential for controlling the development of PGIA.
A controlled balance between initiation and downregulation of immune responses (peripheral tolerance) is important for maintaining immune homeostasis, whereas dysfunctional immune regulation may lead to chronic inflammation or autoimmunity [ 29 ] . The CD4 +CD25 +regulatory T cells have been shown to suppress autoimmunity in several animal models [ 2 ] . To evaluate the role of the CD4 +CD25 +regulatory T cells in PGIA, three approaches were used.
This finding excludes the possibility that reduced expression of CTLA-4 in the CD4 +CD25 +regulatory T cells from BALB/c mice with PGIA may mediate the induction of the disease.
AICD = activation-induced cell death; CTLA = cytotoxic T-lymphocyte antigen; ELISA = enzyme-linked immunosorbent assay; FITC = fluorescein isothiocyanate; IL = interleukin; PE = R-phycoerythrin; PG = proteoglycan; PGIA, proteoglycan-induced arthritis; SCID = severe combined immunodeficient; TCR = T-cell receptor; TGF = transforming growth factor; WT = wild-type.
To elucidate the role of these regulatory T cells in autoimmune arthritis, we first followed up the CD4 +CD25 +-expressing regulatory T cells in mice with PGIA during the entire course of immunization.