Words similar to pgia
Example sentences for: pgia
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The inability of the CD4 +CD25 +regulatory T cells to suppress PGIA was not due to loss of their suppression activity, because in vitro the CD4 +CD25 +T cells could effectively inhibit the proliferation of the CD4 +CD25 -T cells (Fig.
To investigate whether a deficiency in the CD4 +CD25 +regulatory T cells may lead to an increase in the development of PGIA, we immunized wild-type and CD28-deficient BALB/c mice with proteoglycan, and disease incidence was monitored.
In induced models of autoimmunity, the CD28-B7 interaction has been shown to regulate disease susceptibility by rendering autoreactive T cells anergic, or alternatively by upregulating the threshold for autoreactive T-cell activation [ 30 ] . Furthermore, we previously showed that impaired Fas-mediated activation-induced cell death (AICD) of autoreactive T-helper-1 cells may be responsible for the development of PGIA [ 20 ] . Therefore, AICD and/or T-cell anergy, but not the CD4 +CD25 +regulatory T cells, may be responsible for deletion or inactivation of autoreactive T cells in autoimmune arthritis.
3d, right panel), which is consistent with a recent report that the effective function of the CD4 +CD25 +regulatory T cells is T-cell receptor (TCR) specific [ 28 ] . Collectively, our data suggest that the CD4 +CD25 +regulatory T cells may not be involved in the development of PGIA.
A controlled balance between initiation and downregulation of immune responses (peripheral tolerance) is important for maintaining immune homeostasis, whereas dysfunctional immune regulation may lead to chronic inflammation or autoimmunity [ 29 ] . The CD4 +CD25 +regulatory T cells have been shown to suppress autoimmunity in several animal models [ 2 ] . To evaluate the role of the CD4 +CD25 +regulatory T cells in PGIA, three approaches were used.
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