Example sentences for: pgia

How can you use “pgia” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Taken together, our data suggest that the CD4 +CD25 +regulatory T cells may not regulate the development of PGIA.

  • This finding excludes the possibility that reduced expression of CTLA-4 in the CD4 +CD25 +regulatory T cells from BALB/c mice with PGIA may mediate the induction of the disease.

  • 1, BALB/c mice immunized with human cartilage proteoglycan started to develop arthritis after the third injection and the incidence of arthritis reached 100% at day 72 following the third immunization, whereas BALB/c mice immunized with ovalbumin or C57BL/6 mice immunized with proteoglycan were completely resistant to PGIA.

  • In induced models of autoimmunity, the CD28-B7 interaction has been shown to regulate disease susceptibility by rendering autoreactive T cells anergic, or alternatively by upregulating the threshold for autoreactive T-cell activation [ 30 ] . Furthermore, we previously showed that impaired Fas-mediated activation-induced cell death (AICD) of autoreactive T-helper-1 cells may be responsible for the development of PGIA [ 20 ] . Therefore, AICD and/or T-cell anergy, but not the CD4 +CD25 +regulatory T cells, may be responsible for deletion or inactivation of autoreactive T cells in autoimmune arthritis.

  • Our data suggest that the CD4 +CD25 +regulatory T cells might not be essential for controlling the development of PGIA.


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