Example sentences for: pgj

How can you use “pgj” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Both AG126 (10 μM) and 15d-PGJ 2 (1 μM) could prevent H 2 O 2 induced cytotoxicity in ARPE-19, a set of experiments was also performed to determine whether these two agents had additive saving effects.

  • 15d-PGJ 2 , 15-deoxy-delta 12, 14-PGJ 2 ; AP-1, activator protein-1; ERK, p42/44, Extracellular signal-Regulated Kinase; LDL, low density lipoprotein; MAP kinases, Mitogen-Activated Protein kinases; MTT (3-(4,5-dimethylthiazole-2yl)-2,5-diphenyltetrazolium bromide); PCD, programmed cell death; PPARs, peroxisome proliferator-activated receptors; SAPK/JNK, Stress-Activated Protein Kinase/ c-Jun NH2-terminal Kinase.

  • While 1.4 mM H 2 O 2 treatment reduced the viability to ~40% of control, AG126 raised this viability to ~55% of control and 15d-PGJ 2 raised the viability to 75% of control.

  • Results indicated that 15d-PGJ 2 could prevent 25-OH-cholesterol induced cell death in a dose-dependent manner.

  • The cell death can be prevented partially by AG126, and the prostaglandin derivative, 15d-PGJ 2. These agents may be useful pharmacological tools in the future capable of preventing oxidative stress induced RPE cell death in human ocular diseases.


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