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Example sentences for: pdtc
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Alternatively, a pseudomonad ancestor could have contained the genes for and produced pdtc, but this function could have been lost from most strains.
Pyridine-2,6-bis(thiocarboxylic acid) (pdtc) is an iron-regulated metabolite produced by certain pseudomonads that is highly reactive towards metals by virtue of a pair of thiocarboxylate groups and ring nitrogen that combine to form a non-specific, high affinity, tri-dentate ligand (Figure 1) [ 1 2 ] . The formation constants for Co, Cu, and Fe complexes of pdtc were determined to be greater than 10 33 [ 3 ] . Uptake studies using 59Fe showed that addition of pdtc to the growth medium of two different pdtc-producing pseudomonads increased the efficiency of iron uptake by 20% [ 1 ] . The contribution of pdtc to iron uptake may be due to the fact that the copper complex of pdtc (Cu:pdtc) has the ability to reduce both soluble and mineral forms of ferric iron) [ 1 ] . Not surprisingly, in light of its high affinity for essential metals, pdtc also exhibits antimicrobial activity [ 4 ] .
Loss of this function is plausible if pdtc production is a highly specialized function or is only required for survival in extreme or competitive environments.
The relative rarity of pdtc production among pseudomonads, especially the P. stutzeri strains, is consistent with the hypothesis that Ps-moeZ was acquired through LGT by strain KC.
In either case, MoeZ is essential to pdtc synthesis in P. stutzeri strain KC, and pdtc is a potent and versatile molecule.
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