Words similar to pcna
Example sentences for: pcna
How can you use “pcna” in a sentence? Here are some example sentences to help you improve your vocabulary:
Previously, we [ 1 ] found that upon overexpression of Hoxc-8, the vertebral cartilages accumulate immature chondrocytes, and we showed that these cells are proliferating cells by virtue of staining for Proliferating Cell Nuclear Antigen (PCNA).
The authors studied the expression of two p53-upregulated genes ( Cdkn1a , which encodes p21, and Mdm2 ) and one downregulated gene ( Pcna ) in p53-positive tumours after irradiation and showed responses indicative of normal p53 function.
For instance, they are dispensable for DNA damage-dependent activation of the Rad26/Rad3-kinase complex [ 18 ] , but are required for the Rad3-dependent phosphorylation of Chk1 [ 23 ] . Structural predictions of Hus1, Rad1 and Rad9 have led to the proposal that all three fold similarly to the subunits of Proliferating Cell Nuclear Antigen (PCNA) [ 24 25 26 ] . Consistent with these predictions, PCNA exists as a homotrimer [ 27 ] while Hus1, Rad1 and Rad9 all interact and possibly form a heterotrimer [ 25 28 ] . In addition, Rad17 has sequence similarity and physical interactions with subunits of Replication Factor C (RFC) [ 29 30 ] . Based on the RFC-PCNA paradigm, the Rad17-RFC complex may load the PCNA-like Rad9-Rad1-Hus1 (9-1-1) complex onto genomic lesions discovered by the Rad26/Rad3 complex.
A proposed mechanism of SAHA stresses the involvement of pRb2/p130-E2F-4 interaction and nuclear localization, which ultimately results in cell growth arrest and repression in nuclear E2F-1 and PCNA protein levels, and the subsequent inhibition of DNA synthesis in both cell lines.
8A), PNN analysis shows that the increased expression of cyclin D2, p57, and Cdc25a, as well as decreased expression of PCNA, best discriminate control from SN50-treated explants.
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