Words similar to pck
Example sentences for: pck
How can you use “pck” in a sentence? Here are some example sentences to help you improve your vocabulary:
Overall, LC-PUFA may up regulate Pck1, the rate-limiting enzyme in gluconeogenesis, via cAMP-, SREBP-1- and/or PPAR-signaling [ 57 ] . This has the overall effect of limiting fat accumulation and shunting metabolic flux to gluconeogenesis.
The Pck1 promoter can thus exist in altered states of cAMP responsiveness, depending on the transcription factors bound to CRU elements [ 55 ] . In hepatocytes, SREBP-1c can block transcriptional induction of cAMP on PEPCK-C metabolic action [ 56 ] .
Feeding of all three LC-PUFA diets led to an approximately 2* fold increase in hepatic Pck1 for each probe set identified.
Numerous hepatic genes containing SRE promoters were regulated by LC-PUFA in the present experiments, including SREBP-1 itself (consistent with [ 35 36 ] ). Also regulated were genes involved in triacylglycerol synthesis (Gpam), FA synthesis and elongation (Acas1, Acly, FA synthase, Spot14, Elovl2; Elovl2 may speculatively contain an SRE as described by Moon and colleagues [ 35 ] ), FA desaturation (Scd1), gluconeogenesis (Pck1), cytochrome p450 metabolism (Cyp4a-10 and -14), FA transport (Cd36), cholesterol metabolism and transport (Fpps), and ketone body formation (mitochondrial Hmgcs2).
In the liver, cAMP regulates Pck1 transcription via the binding of CREB, as well as CCAAT/enhancer binding protein (C/EBP), to the CRU.
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