Example sentences for: pck

How can you use “pck” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • HNF3γ-signaling may regulate transcription of Pck1 (up regulated ca. 2* fold with each diet, presently), and G6pc (differentially regulated in the current experiment) [ 42 ] . HNF3γ is also reported to increase transcription of several genes that were not differentially regulated in the present experiment including, transferrin, tyrosine amino transferase [ 43 ] , and IPF-1/PDX-1 [ 40 ] .

  • The signaling pathways affecting Pck1 transcription are discussed in the section "cAMP signaling/links to carbohydrate metabolism".

  • The Pck1 promoter can thus exist in altered states of cAMP responsiveness, depending on the transcription factors bound to CRU elements [ 55 ] . In hepatocytes, SREBP-1c can block transcriptional induction of cAMP on PEPCK-C metabolic action [ 56 ] .

  • In the liver, cAMP regulates Pck1 transcription via the binding of CREB, as well as CCAAT/enhancer binding protein (C/EBP), to the CRU.

  • Phosphoenolpyruvate carboxykinase (Pck1) is the rate-limiting enzyme of gluconeogenesis, and most of its activity is regulated transcriptionally.


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