Words similar to pcna-like

Example sentences for: pcna-like

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The TBZ-data shown here suggest that at least Rad1 and Rad9 have roles that are independent of their function in the PCNA-like clamp.
For instance, they are dispensable for DNA damage-dependent activation of the Rad26/Rad3-kinase complex [ 18 ] , but are required for the Rad3-dependent phosphorylation of Chk1 [ 23 ] . Structural predictions of Hus1, Rad1 and Rad9 have led to the proposal that all three fold similarly to the subunits of Proliferating Cell Nuclear Antigen (PCNA) [ 24 25 26 ] . Consistent with these predictions, PCNA exists as a homotrimer [ 27 ] while Hus1, Rad1 and Rad9 all interact and possibly form a heterotrimer [ 25 28 ] . In addition, Rad17 has sequence similarity and physical interactions with subunits of Replication Factor C (RFC) [ 29 30 ] . Based on the RFC-PCNA paradigm, the Rad17-RFC complex may load the PCNA-like Rad9-Rad1-Hus1 (9-1-1) complex onto genomic lesions discovered by the Rad26/Rad3 complex.
Studies suggest that Hus1, Rad1, and Rad9 function together to form a PCNA-like clamp complex that is loaded onto DNA by Rad17 [ 16 ] . This model predicts that all four proteins should show the same levels of TBZ sensitivity since deletion of any of the four proteins should prevent formation of a functional clamp.