Example sentences for: pathway

How can you use “pathway” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The Hh-blocking antibody 5E1 had no effect on pathway activation by the agonist (Figure 4b), while forskolin (Figure 4c), cyclopamine (Figure 4d) and Cur61414 (Figure 4e), were all inhibitory.

  • It was anticipated that the presence of a constitutively active Syk enzyme could help in delineating the signaling events that occur upstream and downstream of Syk activation in the BCR signal transduction pathway.

  • APC mutations have been identified in medulloblastoma cell lines and up to 4% of sporadic medulloblastomas [ 16 17 ] . Furthermore, point mutations or small deletions in β- catenin exon 3 have been identified in 5-10% of sporadic medulloblastomas and in supratentorial primitive neuroectodermal tumors (PNETs) [ 17 18 19 ] . Finally, large deletions in AXIN were recently found in 12% of sporadic medulloblastomas [ 20 ] . In the absence of Wnt signaling β-catenin is sequestered in the cytoplasm, and nuclear translocation of β-catenin has been used to monitor activation of the Wnt pathway in a number of different tumor types.

  • Periplasmic pathway remnants?

  • If the pathway had evolved in a retrograde direction, the Horowitz theory would postulate that GshB arose to take advantage of γ-Glu-Cys present in the environment.


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