Words similar to pathway
Example sentences for: pathway
How can you use “pathway” in a sentence? Here are some example sentences to help you improve your vocabulary:
Furthermore, experimental evidence suggests that when a signaling network is activated, positive feedback mechanisms upregulate the expression of genes that encode pathway proteins [ 26 ] , implying that this rationale is also applicable to "surveillance" pathways, whose protein components may need to be constitutively present in small quantities, but whose concentration increases with activation.
IL-2 administration is also associated with potent systemic toxicity that limits its therapeutic usefulness [ 8], and a relationship between toxicity and clinical effectiveness has been observed, suggesting a common effector pathway [ 9].
These data suggest that 5-HT does not activate the p38 pathway in rat vascular smooth muscle cells despite the ability of other agonists to activate the pathway in these cells.
StAR plays a key role in the initial steps of steroidogenesis, because it is required for transport of cholesterol to the inner mitochondrial membrane where CYP11A1 resides and the first reaction in progesterone synthesis occurs [ 45 ] . cAMP is a well known second messenger in FSH- and LH-stimulated progesterone synthesis, and a key effect of the cAMP-dependent protein kinase in GC is transcriptional control of StAR [ 46 47 ] . Estradiol is recognized as a biological amplifier of basal, FSH- and cAMP-stimulated progesterone production in pig GC, with significant synergistic effects distal to the generation of cAMP at one or more steps in cholesterol transport and metabolism [ 48 ] . Our experimental results are thus consistent with 4-AP inhibition of GC progesterone output via drug effects on multiple interacting sites in the steroidogenic pathway.
A549 cells were grown to 50-80% confluence on 12-well plates and transfected with the Mercury pathway profiling system vector, pNFκB-TA-Luc (Clontech, Palo Alto, CA, USA), using lipofectamine (Gibco/BRL, Rockville, MD, USA) and used according to the manufacturer's recommendations.
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