Example sentences for: pathologies

How can you use “pathologies” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The diagnosis of HF is generally made on the basis of signs and symptoms that may overlap with those of other cardiovascular and pulmonary pathologies.

  • In summary, in our experiments the in vitro effect of a 1-6 hour exposure to domoic acid on rat neonatal microglia activation and concomitant TNF-α, MMP-9 and O 2 - release was clearly distinct in its magnitude from that observed after exposure to LPS, an agent involved in endotoxic shock and other central nervous pathologies [ 3 ] . Even though this present study was limited to the study of the in vitro effects of domoic acid on three microglia mediators, namely TNF-α, MMP-9 and O 2 -, it provides the first experimental evidence to our knowledge that domoic acid, at in vitro concentrations that are toxic to neuronal cells, can trigger a limited activation of rat neonatal microglia and the concomitant release of modest though statistically significant amounts of TNF-α and MMP-9.

  • These findings assume clinical importance since they may explain in part the chronic and autoimmune pathologies in the elderly, particularly rheumatoid arthritis, Crohn's disease, sepsis, and myelodysplastic syndromes, which are exacerbated by the inflammatory cytokines IFN-γ and TNF-α [ 41 ] . Likewise, the elevation of these cytokines, particularly TNF-α potentially may contribute to the deterioration in the HIV +or AIDS patient by promoting wasting and cachexia [ 42 ] .

  • Unless these exploding social pathologies are reversed, they will lead to the decline and perhaps even to the fall of the American republic

  • TNF-α is a cytokine that can mediate myelin and oligodendrocyte damage in vitro [ 10 ] and thought to play a key role in central nervous system pathologies [ 3 ] . In vitro E. coli LPS can trigger rat neonatal microglia to rapidly activate TNF-α gene expression and subsequent protein release [ 46 ] in a concentration- and time-dependent manner.


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