Example sentences for: pathologic

How can you use “pathologic” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Stimulation of RAR α and γ mRNA in LNCaP cells by T differed from that in normal rat prostate and non-tumorigenic rat prostate epithelial cells (NRP-152), but was comparable to that in tumorigenic rat prostate epithelial cells (NRP-154) [ 13 14 ] . In cervical carcinoma cells, the RAR β gene was abnormally down-regulated by RA [ 36 ] . In ER positive human breast cancer cells, RAR α mRNA was also up-regulated by estrogen [ 16 ] . Thus, T stimulation of RAR mRNAs in LNCaP cells could be related to the pathologic state of the cells.

  • It has been suggested that pathologic activation of the mucosal immune system in response to antigens is a key factor in the pathogenesis of IBD.

  • Previously reported microarray studies of female Rett and unrelated control brain samples revealed expression changes that were interpreted as secondary to the disease process, such as increased expression of glial-specific genes and decreased expression of neuronal genes [ 25 ] . Therefore, when searching for the primary targets of MeCP2 modulation, it might be advantageous to study a tissue that is less obviously involved in the pathologic processes of the disease.

  • Although the pathologic processes that underlie the development of erosions are incompletely understood, a considerable body of evidence has suggested that a pannus of cells that originate in chronically inflamed, proliferative synovial tissue becomes locally invasive, and enzymatically degrades the matrix of the articular cartilage and periarticular bone [ 4].

  • Tumor stage is the most significant prognostic parameter for 5-year survival, but even patients with non-small cell lung cancer (non-SCLC) in pathologic stage IA disease (a tumor of less than 3 cm diameter located in one lobe of the lung and more than 2 cm from the carina without visceral pleural involvement, atelectasis, or pneumonitis, and absence of metastatic spread to regional lymph nodes) have a 33% chance of recurrence within 5 years after complete surgical resection (lobectomy with mediastinal lymph node dissection) [ 2].


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