Words similar to orthologues
Example sentences for: orthologues
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The single signature sequence of bacterial RNase III orthologues not only provides residues essential for catalysis, but contributes to the subunit interface [ 12 ] . It is therefore likely that mouse RNase III is active as a homodimer.
Note also that Drosophila RNase III has a serine-rich C-terminal extension [ 19 ] . There are two catalytic domain signature sequences present in these orthologues.
Two mammalian RNase III orthologues have been identified, and exhibit common domains as well as apparently unique features.
This strategy resulted in the identification of the murine orthologues of EVER1 and EVER2, and four hitherto uncharacterized human and mouse proteins (Figure 1, Table 1).
Also collected in the set for comparison were the previously-described Runx genes from D. melanogaster ( runt and lozenge [ 7 ] ), Caenorhabditis elegans ( run [ 8 ] ), sea urchin ( SpRunt [ 9 10 ] ), T. rubripes ( TrRunx2 [ 11 ] ), and mouse ( Runx1 , Runx2 , and Runx3 ; the three human RUNX genes, which have been extensively characterized previously, are highly similar to their mouse orthologues [ 12 13 ] and hence were not included in the collected set).