Words similar to orthologues
Example sentences for: orthologues
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In vertebrates (from the proximal promoter), the Runx3 orthologues each contain 2 exons downstream of the Runt domain, while the Runx2 orthologues contain 4 and the
Among the insect representatives, each of the mosquito genes can be confidently assigned orthologues from Drosophila (Fig.
It is clear from these data that the usage of alternative promoters evolved prior to the gene duplication events in the vertebrate lineage, since all three genes in both mouse and Takifugu utilize alternative promoters that give rise to similar alternative N-termini within the respective orthologues.
Runx1 orthologues contain 3. CiRunt contains 5 exons downstream of the Runt domain, while CeRun contains 4. In vertebrates at least, the multiplicity of downstream exons is reflected in a large variety of alternatively spliced transcripts that give rise to multiple protein isoforms that differ in the C-terminal sequences appended to the Runt domain [ 12 13 ] . It is important to note that the C-terminal exon of all Runx genes identified to date encodes the amino acid sequence VWRPY (or the functionally equivalent IWRPF in the case of C. elegans ), which acts as a recruitment motif for the co-repressor Groucho/TLE [ 3 ] . This motif is at the C-terminus within the 3'-most exon of all of the genes, possibly with the exception of CiRunt (where the open reading frame apparently continues beyond the VWRPY in the genome sequence), and was used in our analysis to identify the C-terminal exons of previously uncharacterised Runx genes.
Except for the lozenge orthologues, which contain two such exons, all of the insect genes for which complete sequences are available contain only a single exon downstream of the Runt domain.
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