Words similar to orthologues
Example sentences for: orthologues
How can you use “orthologues” in a sentence? Here are some example sentences to help you improve your vocabulary:
Runx1 orthologues contain 3. CiRunt contains 5 exons downstream of the Runt domain, while CeRun contains 4. In vertebrates at least, the multiplicity of downstream exons is reflected in a large variety of alternatively spliced transcripts that give rise to multiple protein isoforms that differ in the C-terminal sequences appended to the Runt domain [ 12 13 ] . It is important to note that the C-terminal exon of all Runx genes identified to date encodes the amino acid sequence VWRPY (or the functionally equivalent IWRPF in the case of C. elegans ), which acts as a recruitment motif for the co-repressor Groucho/TLE [ 3 ] . This motif is at the C-terminus within the 3'-most exon of all of the genes, possibly with the exception of CiRunt (where the open reading frame apparently continues beyond the VWRPY in the genome sequence), and was used in our analysis to identify the C-terminal exons of previously uncharacterised Runx genes.
One strategy was based on a previous study [ 35 ] which identified eukaryotic RNase III orthologues by a BLAST search of the NCBI translated mouse EST database, using E. coli RNase III as query sequence.
Given a procedure that gave a list of orthologues for the human gene query, such situations should be revealed by only partial (or complete absence of) agreement between the annotations of the wheat orthologs.
It is interesting that the pufferfish genome lacks orthologues of mammalian TMC1 and TMC8.
Also collected in the set for comparison were the previously-described Runx genes from D. melanogaster ( runt and lozenge [ 7 ] ), Caenorhabditis elegans ( run [ 8 ] ), sea urchin ( SpRunt [ 9 10 ] ), T. rubripes ( TrRunx2 [ 11 ] ), and mouse ( Runx1 , Runx2 , and Runx3 ; the three human RUNX genes, which have been extensively characterized previously, are highly similar to their mouse orthologues [ 12 13 ] and hence were not included in the collected set).
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